Effect of Intravenous Grnisetron on Intraocular Pressure

Eldeen, Hala M. Bahy; Sameer, Dalia; Fahim, Mona R.; Shouman, Ayman
August 2010
Journal of Applied Sciences Research;Aug2010, Vol. 6 Issue 8, p1215
Academic Journal
Background: Prevention of rise of intraocular pressure (IOP) is essential in patients undergoing surgery for perforating eye injuries. Granisetron is a potent antiemetic can be used to prevent nausea and vomiting in perforated injuries. Aim: to study the effect of Granisetron when given IV on IOP. Methods: A randomized double-blind, placebo-controlled study of 60 patients undergoing strabismus surgery. Patients are divided into 2 groups, (group C) received normal saline or (group G) received Granisetron 1 mg 5 min. before induction. Intraocular pressure was measured for 5 readings by Perkin Applanation Tonometer. Results: there is insignificant decrease in IOP in (group G) after Granisetron. IOP decreased in both groups significantly after Thiopentone and increased also significantly after Succinylcholine administration and intubation. The measurements were comparable in all groups at all times. Conclusion: Granisetron doesn't cause any significant change in I.O.P nor does it influence the changes in I.O.P during anesthesia and intubation so it can be used safely in perforated eye injuries.


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