New Delhi metallo-Î²-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection
- An enzoinformatics study for prediction of efficacies of three novel penem antibiotics against New Delhi metallo- Î²-lactamase-1 bacterial enzyme. Ansari, Mohd.; Shaikh, Sibhghatulla; Shakil, Shazi; Rizvi, Syed // Interdisciplinary Sciences: Computational Life Sciences;Sep2014, Vol. 6 Issue 3, p208
New Delhi metallo-beta-lactamase (NDM-1) is a beta-lactamase (class B carbapenemase) containing Zn and other divalent cations as cofactors which possesses the ability to inactivate all beta lactams (including carbapenems) except aztreonam by catalyzing the hydrolytic cleavage of the substrate...
- Lack of beta- lactamases in Pseudomonas aeruginosa of animal origin and water. Cicuta, M. E; Roibón, W. R.; Barcelo, M. C.; Arzu, O. R.; Amable, V. J // Revista Veterinaria;2011, Vol. 22 Issue 1, p3
In order to know the susceptibility to carbapenems (imipenem and meropenem), ceftazidime and aztreonam as phenotypical indicator substrates of Î²-lactamases, 30 strains of Pseudomonas aeruginosa (18 from animal clinical samples and 12 from non- chlorinated water) were analysed. There were not...
- Molecular characterization of extended-spectrum beta-lactamases (ESBLs) produced by clinical isolates of Acinetobacter baumannii in Saudi Arabia. Alyamani, Essam J.; Khiyami, Mohamed A.; Booq, Rayan Y.; Alnafjan, Basel M.; Altammami, Musaad A.; Bahwerth, Fayez S. // Annals of Clinical Microbiology & Antimicrobials;Aug2015, Vol. 14 Issue 1, p1
Background: Acinetobacter baumannii is a common opportunistic pathogen that causes major nosocomial infections in hospitals. In this study, we hypothesized a high prevalence of A. baumanni ESBL (extended-spectrum beta-lactamase) among all collected isolates. Methods: A. baumannii isolates (n =...
- "Super Superbug" NDM-1 Spreads in Europe. // Clinical Infectious Diseases;2/15/2011, Vol. 52 Issue 4, pi
The article reports on the concern expressed by Dominique Monnet of the European Centre for Disease Prevention and Control (ECDC) regarding the emergence of New Delhi metallo-beta-lactamase (NDM-1) and other bugs that are resistant to carbapenems, the most powerful class of antibiotics.
- Detection of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae producing NDM-1 in Lebanon. El-Herte, Rima I.; Araj, George F.; Matar, Ghassan M.; Baroud, Maysa; Kanafani, Zeina A.; Kanj, Souha S. // Journal of Infection in Developing Countries;May2012, Vol. 6 Issue 5, p457
Carbapenem resistance has been encountered globally with poor outcome of infected patients. NDM-1 (New Delhi metallo-beta-lactamase) gene containing organisms have emerged and are now spreading in all continents. This is the first report of Iraqi patients referred to Lebanon from whom carbapenem...
- Tackling the Superbug. // India Today;8/30/2010, p23
The article deals with New Delhi Metallo beta lactamase-1 (NDM-1), a potentially fatal disease which causes gastric problems. Believed to originate in India, it was discovered on January 9, 2008 by Swedish scientists. NDM-1 is adaptive, and carbapenem, the only antibiotic effective against the...
- Emergence of NDM-1-producing Acinetobacter baumannii in China. Yan Chen; Zhihui Zhou; Yan Jiang; Yunsong Yu // Journal of Antimicrobial Chemotherapy (JAC);Jun2011, Vol. 66 Issue 6, p1255
Objectives To investigate the prevalence of blaNDM-1 in Gram-negative bacilli in China. Methods A total of 11 298 clinical Gram-negative bacilli, covering Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa, were collected for PCR-based surveillance of...
- Sterilization of Endoscopic Instruments. Mattke, Soeren // JAMA: Journal of the American Medical Association;2/3/2015, Vol. 313 Issue 5, p524
A letter to the editor is presented in response to the article "New Delhi Metallo-Î²-lactamase-Producing Carbapenem-Resistant Escherichia coli Associated with Exposure to Duodescopes," by I. Epstein et al. in the 2014 issue.
- Sterilization of Endoscopic Instruments. Rutala, William A.; Weber, David J. // JAMA: Journal of the American Medical Association;2/3/2015, Vol. 313 Issue 5, p524
A response by William A. Rutala and David J. Weber to a letter to the editor about their article "New Delhi Metallo-Î²-lactamase-Producing Carbapenem-Resistant Escherichia coli Associated with Exposure to Duodescopes," in the 2014 issue is presented.