TITLE

Short-term opioids for breathlessness in stable chronic heart failure: a randomized controlled trial

AUTHOR(S)
Oxberry, Stephen G.; Torgerson, David J.; Bland, J. Martin; Clark, Andrew L.; Cleland, John G.F.; Johnson, Miriam J.
PUB. DATE
September 2011
SOURCE
European Journal of Heart Failure;Sep2011, Vol. 13 Issue 9, p1006
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aims To assess the effect of oral opioids vs. placebo on breathlessness in patients with chronic heart failure (CHF). Methods and results Oral morphine (Oramorph), oral oxycodone (Oxynorm), and placebo were studied in an outpatient setting. Once randomized, participants received all three interventions in a controlled double-blind crossover trial for 4 days each, with a 3-day washout between interventions. Patients known to the Hull and East Yorkshire Academic Cardiology department with CHF (New York Heart Association Grade III�IV) were invited to participate. Participants were eligible if they were on standard medical therapy with angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, and diuretics. Conclusion We demonstrated no benefit over placebo for the relief of breathlessness with short-term low-dose oral opioids for CHF patients.
ACCESSION #
64856034

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics