TITLE

Recombinant Human Bone Morphogenetic Protein-2 Conined by an Imperforate Titanium Shell over High-Profile Dental Implants in Rabbit Tibiae: A Pilot Bone Augmentation Study

AUTHOR(S)
Casap, Nardy; Laster, Zvi; Laviv, Amir; Debecco, Meir; Alterman, Michael; Cottam, Jared; Jensen, Ole T.
PUB. DATE
June 2011
SOURCE
Oral & Craniofacial Tissue Engineering;2011, Vol. 1 Issue 2, p141
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: To evaluate the use of a nonperforated titanium occlusive device over a bone morphogenetic protein-2 in an absorbable collagen sponge (BMP-2/ACS) in grafting the bone around high-profile (ie, supracrestal) dental implants in rabbit tibiae. Materials and Methods: Eight New Zealand white rabbits were used for the experiment. Two implants were placed in the right tibia of each rabbit, with 4 mm of each implant placed supracrestally ("high-profile" placement) in four groups of two rabbits each: control, titanium shell only, titanium shell over buffered collagen, and titanium shell over BMP-2/ACS. The animals were sacrificed after 3 or 6 weeks. Calcified and nondecalcified histologic preparation was carried out to evaluate bone formation and degree of osseointegration. Results: Three of the eight animals developed tibial fractures. The two BMP-2 test animal tibiae remained intact, with the 3-week specimen showing very little bone formation inside or outside of the titanium chamber and the 6-week specimen showing bone mostly outside of the chamber. Conclusion: The placement of BMP-2 beneath an occlusive nonperforated titanium shell next to a high-profile implant did not result in significant bone formation.
ACCESSION #
64753605

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics