The unr Gene: Evolutionary Considerations and Nucleic Acid-Binding Properties of Its Long Isoform Product
- Axonal transport of recombinant baculovirus vectors. Li, Ying; Wang, Xu; Guo, Haiyan; Wang, Shu // Molecular Therapy;Dec2004, Vol. 10 Issue 6, p1121
Abstract: Targeted gene delivery to neurons is crucial to effective gene therapy of neurodegenerative diseases. Several types of viral gene vectors may target neurons through retrograde axonal transport to somas of projection neurons after viral internalization at axon terminal fields. In this...
- Automated Acquisition of Aptamer Sequences. Cox, J. Colin; Rajendran, Manjula; Riedel, Timothy; Davidson, Eric A.; Sooter, Letha J.; Bayer, Travis S.; Schmitz-Brown, Mayer; Ellington, Andrew D. // Combinatorial Chemistry & High Throughput Screening;Jun2002, Vol. 5 Issue 4, p289
While the in vitro selection of nucleic acid binding species (aptamers) requires numerous liquidhandling steps, these steps are relatively straightforward and the overall process is therefore amenable to automation. Here we demonstrate that automated selection techniques are capable of...
- chaotropic agent. // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p418
A definition of the medical term "chaotropic agent," which refers to an ion that causes disruption in membranes, nucleic acids and proteins, is presented.
- In vitro selection of nucleoprotein enzymes. Robertson, Michael P.; Ellington, Andrew D. // Nature Biotechnology;Jul2001, Vol. 19 Issue 7, p650
Natural nucleic acids frequently rely on proteins for stabilization or catalytic activity. In contrast, nucleic acids selected in vitro can catalyze a wide range of reactions even in the absence of proteins. To augment selected nucleic acids with protein functionalities, we have developed a...
- Synthetic biology: Assemble-on-a-chip. // Nature Methods;Jul2012, Vol. 9 Issue 7, p644
The article focuses on a study conducted by researchers to create biodevices that can help in understanding molecule synthesis, assembly and imaging of protein and nucleic acids.
- Biochemistry: Proteins masquerading as DNA for efficient delivery. // Nature Methods;Jan2015, Vol. 12 Issue 1, p15
The article offers information on a study by J.A. Zuris and others which focuses on the direct delivery of proteins by cationic liposomal reagents, which is routinely used for nucleic acid delivery.
- Multiple Target Detection Just Got Easier. Janssen, Deborah // Genomics & Proteomics;Oct2002, Vol. 2 Issue 8, p13
Describes the eTag Assay System developed by Mountain View, California-based Biosciences Inc. for the high-throughput analysis of protein and nucleic acids. Development of the technology based on polymerase chain reaction where we could detect multiple gradients; Defined electrophoretic...
- Hormones and Macromolecules. Ferguson Jr., James J. // Annals of Internal Medicine;May64, Vol. 60 Issue 5, p925
Editorial. Reviews studies on the effects of hormones on nucleic acid and protein metabolism in target tissues. Mechanisms of hormonal action; Nature of tissues included in studies; Hormones linked to alterations in metabolism.
- Hamster polyomavirus-derived virus-like particles are able to transfer in vitro encapsidated plasmid DNA to mammalian cells. Tatyana Voronkova; Andris Kazaks; Velta Ose; Muhsin Özel; Siegfried Scherneck; Paul Pumpens // Virus Genes;Jun2007, Vol. 34 Issue 3, p303
AbstractÂ Â The authentic major capsid protein 1 (VP1) of hamster polyomavirus (HaPyV) consists of 384 amino acid (aa) residues (42Â kDa). Expression from an additional in-frame initiation codon located upstream from the authentic VP1 open reading frame (at position âˆ’4) might result...