TITLE

Abnormal Restriction Pattern of PIP Gene Associated with Human Primary Prostate Cancers

AUTHOR(S)
Autiero, Monica; Culerrier, Raphael; Bouchier, Christiane; Basmaciogullari, Stephane; Gaubin, Muriel; Marhomy, Sandrine El; Blanchet, Pascal; Paradis, Valerie; Jardin, Alain; Guardiola, John; Piatier-Tonneau, Dominique
PUB. DATE
June 1999
SOURCE
DNA & Cell Biology;Jun99, Vol. 18 Issue 6, p481
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The PIP gene, localized in the 7q34 region that contains a number of fragile sites such as FRA 7H and FRA TI, codes for gp17/PIP, a protein secreted by breast apocrine tumors. We analyzed the integrity of this gene in 20 tumors of the urogenital tract. We found rearranged Eco RI fragments in 5 of 15 primary prostate carcinomas. No rearrangement was found in normal prostates derived from five patients undergoing prostatocystectomy during treatment of bladder cancers. By Southern blot hybridization with PIP gene exon-specific probes, the rearrangements were mapped at or near the 3' end of the gene. These abnormalities were found, not only in the neoplastic cells invading the prostatic tissues, but also in seminal vesicles without histologic tumoral features. These data suggest a critical role of the PIP gene or neighboring genes in prostate cancer.
ACCESSION #
6463028

 

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