Targeting of Hepatitis C Virus Core Protein for MHC I or MHC II Presentation Does Not Enhance Induction of Immune Responses to DNA Vaccination
- VIRAL IMMUNITY: Stop! Bell, Elaine // Nature Reviews Immunology;Feb2002, Vol. 2 Issue 2, p74
Focuses on the mechanisms employed by hepatitis C virus (HCV) to promote chronic infection. Result of crosslinking CD81 with HCV envelope protein E2; Function of CD81; Inhibition of the Interferon-Î³ production in response to NK-cell stimulation by the cytokines interleukins.
- Differential alteration of CD56 and CD56 natural killer cells in frequency, phenotype, and cytokine response in chronic hepatitis C virus infection. Miyagi, Takuya; Shimizu, Satoshi; Tatsumi, Tomohide; Nishio, Kumiko; Hiramatsu, Naoki; Kanto, Tatsuya; Hayashi, Norio; Takehara, Tetsuo // Journal of Gastroenterology;Aug2011, Vol. 46 Issue 8, p1020
Background: Natural killer (NK) cells play an important role in immune responses to virus infection. The cell population consists of CD56 (bright-subset) and CD56 (dim-subset) subsets that possess armed functions of cytokine production and cytolysis, respectively. How these subsets are involved...
- Soluble CD26 and CD30 Plasma Levels in HIV Infected Patients with and Without GB Virus Type C Coinfection. Mostafa, Haji-Molla-Hoseini; Ali-Akbar, Pourfathollah; Zahra, Soheili; Minoo, Mohraz; Sedigheh, Amini; Mahnaz, Aghaiepour; Shahram, Samiee; Mahin, Nikoogoftar; Mina, Moghtadaie // Pakistan Journal of Biological Sciences;2007, Vol. 10 Issue 12, p2014
GB virus type C (GBV-C) probably influences HIV infection associated disease by either directly inhibiting HIV replication or enhancing the immune competence to cope with HIV. Still the definitive mechanisms of this inhibitory effect need to be identified. To address the possibility of immune...
- Phenotypic and functional alterations of primary human PBMCs induced by HCV non-enveloped capsid-like particles uptake. Doumba, Polyxeni; Serti, Elisavet; Boutsikou, Maria; Konstadoulakis, Manousos; Georgopoulou, Urania; Koskinas, John // Cellular & Molecular Life Sciences;Sep2013, Vol. 70 Issue 18, p3463
Hepatitis C virus non-enveloped particles circulate in the serum of HCV-infected patients and are believed to be involved in viral persistence. It was previously demonstrated that recombinant HCVne particles can efficiently enter T cells. In this study we investigated the effect of this entry on...
- Relationship of peripheral blood CD4-positive T cells to carcinogenesis in patients with HCV-related chronic hepatitis and liver cirrhosis. Matsui, Teppei; Nagai, Hidenari; Sumino, Yasukiyo; Miki, Kazumasa // Cancer Chemotherapy & Pharmacology;Aug2008, Vol. 62 Issue 3, p401
It has been reported that Th2 cytokines down-regulate antitumor immunity, while activation of type 1 T cell responses promotes antitumor immunity. However, detailed information on the immunological background of patients with HCC is still unknown. The objectives of this study were to evaluate...
- CD100 Up-Regulation Induced by Interferon-Î± on B Cells Is Related to Hepatitis C Virus Infection. He, Yu; Guo, Yonghong; Zhou, Yun; Zhang, Ying; Fan, Chao; Ji, Guangxi; Wang, Yu; Ma, Zhiyuan; Lian, Jianqi; Hao, Chunqiu; Yao, Zhi Q.; Jia, Zhansheng // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1
Objectives: CD100, also known as Sema4D, is a member of the semaphorin family and has important regulatory functions that promote immune cell activation and responses. The role of CD100 expression on B cells in immune regulation during chronic hepatitis C virus (HCV) infection remains unclear....
- Chronic Hepatitis C in the United States. Deresinki, Stan // Clinical Infectious Diseases;10/15/2006, Vol. 43 Issue 8, pvi
The article presents the abstract of the paper "The Prevalence of Hepatitis C virus infection in the United States, 1999 Through 2002," by G.L. Armstrong and colleagues.
- CORRECTION. // Annals of Internal Medicine;9/6/2005, Vol. 143 Issue 5, p395
Presents a correction to an article on patient-to-patient transmission of hepatitis C virus, published previously in the periodical "Annals of Internal Medicine."
- Hematologic Disorders Associated with Hepatitis C Virus Infection and Their Management. Dieterich, Douglas T.; Spivak, Jerry L. // Clinical Infectious Diseases;8/15/2003, Vol. 37 Issue 4, p533
More than 4 million people in the United States are infected with hepatitis C virus (HCV). During the next 20-30 years, the burden of HCV-related mortality and morbidity will likely double. To date, the most effective treatment for chronic HCV infection is the combination of either interferon...