TITLE

Dabigatran etexilate: A novel oral direct thrombin inhibitor

AUTHOR(S)
Blommel, Matthew L.; Blommel, Amy L.
PUB. DATE
August 2011
SOURCE
American Journal of Health-System Pharmacy;8/15/2011, Vol. 68 Issue 16, p1506
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose. The pharmacology, pharmacokinetics, clinical efficacy, tolerability, dosage and administration, and place in therapy of dabigatran etexilate are reviewed. Summary. Dabigatran is a reversible direct thrombin inhibitor (DTI) that has rapid and predictable anticoagulant effects and does not require the anticoagulation monitoring seen with oral vitamin K antagonists. Dabigatran etexilate has demonstrated efficacy in several clinical studies in preventing venous thromboembolism (VTE) for patients undergoing total hip or knee replacement, in preventing strokes in patients with nonvalvular atrial fibrillation, and in treating acute VTE. Dabigatran etexilate is a prodrug that is orally absorbed and completely converted to the active form dabigatran by carboxylesterases. Neither the conversion of dabigatran etexilate nor the metabolism of active dabigatran involves the cytochrome P-450 isoenzyme system. Other than hemorrhage, dabigatran is generally well tolerated, with gastrointestinal effects being the most commonly reported adverse events. All dosages should be adjusted in patients with reduced renal function. Dabigatran is currently being investigated for several thromboembolic disorders. It was approved by the Food and Drug Administration in October 2010 for stroke and VTE prevention in adult patients with nonvalvular atrial fibrillation, and it was approved by the European Medicines Agency in March 2009 for the prevention of VTE in adult patients undergoing elective total hip or knee replacement. Conclusion. Dabigatran etexilate, the first oral DTI marketed in the United States, is indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Dabigatran may be a viable option for anticoagulation in some patients due to its oral administration, rapid onset of action, and predictable anticoagulant effects.
ACCESSION #
64451894

 

Related Articles

  • Thrombosis on a Mechanical Aortic Valve whilst Anti-coagulated With Dabigatran Stewart, Ralph A.H.; Astell, Heather; Young, Laura; White, Harvey D. // Heart, Lung & Circulation;Jan2012, Vol. 21 Issue 1, p53 

    There is currently limited evidence on the safety and efficacy of novel oral anticoagulants in patients with mechanical heart valves. This case report describes a patient with a St Jude aortic valve replacement who suffered valve thrombosis and an embolic stroke when anti-coagulated with the...

  • Dabigatran for Stroke Prevention in Nonvalvular Atrial Fibrillation: Answers to Challenging "Real-World" Questions. Ferreira, Jorge; Ferreira, Daniel; Viana-Baptista, Miguel; Bettencourt, Paulo; Cernadas, Rui; Crespo, Francisco // Thrombosis;2012, p1 

    Dabigatran etexilate is a novel, oral, reversible, direct thrombin inhibitor that constitutes a major breakthrough for stroke prevention in patients with nonvalvular atrial fibrillation (AF). Dabigatran was the first new oral anticoagulant approved in Europe and became available in Portugal, for...

  • Breakthrough therapy dabigatran provides consistent benefit across all atrial fibrillation types and stroke risk groups.  // Biomedical Market Newsletter;5/21/2011, p368 

    The article presents the findings of a clinical trial on the effectiveness of dabigatran etexilate in stroke prevention in atrial fibrillation (AF). Based on the study, it is revealed that oral direct thrombin inhibitor dabigatran 150mg bid was able to reduce stroke rates as compared to...

  • Dabigatran etexilate is cost-effective for stroke prevention in atrial fibrillation, particularly in real-world clinical practice.  // Biomedical Market Newsletter;4/30/2011, p537 

    The article reports on the publication of an economic analysis suggesting the cost-effectiveness of Boehringer Ingelheim GmbH's novel oral direct thrombin inhibitor dabigatran etexilate compared to other treatment options in Germany. The cost-effectiveness was driven by superior prevention of...

  • Pros and cons of dabigatran. Cheng, Christine M.; McCurdy, Megan R.; Wong, Heather A.; Kayser, Steven R. // American Journal of Health-System Pharmacy;8/15/2011, Vol. 68 Issue 16, p1495 

    In this article the author discusses the pros and cons of dabigatran etexilate which is the first oral direct thrombin inhibitor and the first oral anticoagulant. It offers details on the limitations of dabigatran and suggests avoiding its use by patients who are unable to swallow the whole...

  • Noi anticoagulante orale. Rugina, Mihaela; Salagean, Mihaela; Predescu, L.; Apetrei, E. // Romanian Journal of Cardiology;Mar2012, Vol. 22 Issue 1, p43 

    Anticoagulant therapy to prevent thromboembolic events and stroke in atrial fibrillation is currently realized by vitamin K antagonists. Numerous drug and food interactions, inter individual variability in dose, and narrow therapeutic window make long-term use of these drugs to be difficult....

  • Coadministration of Dabigatran Etexilate and Atorvastatin: Assessment of Potential Impact on Pharmacokinetics and Pharmacodynamics. Stangier, Joachim; Rathgen, Karin; Stähle, Hildegard; Reseski, Kathrin; Körnicke, Thomas; Roth, Willy // American Journal of Cardiovascular Drugs;2009, Vol. 9 Issue 1, p59 

    Background: Dabigatran etexilate, a novel oral direct thrombin inhibitor, has been approved for prophylaxis of thromboembolism in patients undergoing total knee or total hip replacement, and is under clinical investigation for treatment of venous thromboembolism, prevention of stroke in patients...

  • RE-ALIGN: First trial of novel oral anticoagulant in patients with mechanical heart valves - The search continues. Shazly, Ahmed; Afifi, Ahmed // Global Cardiology Science & Practice;2014, Vol. 2014 Issue 1, p1 

    The article presents results of the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) study on the efficacy of dabigatran etexilate. The study revealed that dabigatran, a direct oral thrombin inhibitor, is more effective compared to warfarin in patients having non-valvular...

  • Dabigatran Etexilate mesylate Capsules (Pradaxa). Elliott, William T. // Internal Medicine Alert;11/29/2010, Vol. 32 Issue 22, p174 

    The article offers information on thrombin inhibitor Dabigatran Etexilate mesylate including its dosage, indications, and clinical implications.

  • Oral Thromboprophylaxis Following Total Hip or Knee Replacement: Review and Multicentre Experience with Dabigatran Etexilate. Kendoff, D.; Perka, C.; Fritsche, H. M.; Gehrke, T.; Hube, R. // Open Orthopaedics Journal;2011, Vol. 5, p395 

    The risk of venous thromboembolism (VTE) in patients undergoing total knee or hip replacement surgery is high. As a result, thromboprophylaxis is highly recommended. While current thromboprophylactic agents, such as low molecular weight heparins (LMWH) and vitamin K antagonists, are safe and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics