Comparing intramuscular progesterone, vaginal progesterone and 17 α-hydroxyprogestrone caproate in IVF and ICSI cycle

Moini, Ashraf; Zafarani, Fatemeh; Eslami, Bita; Sadeghi, Maria; Kamyabi, Zahra; Jahangiri, Nadia
April 2011
Iranian Journal of Reproductive Medicine;Spring2011, Vol. 9 Issue 2, p119
Academic Journal
Background: Supplementation of luteal phase with progesterone is prescribed for women undergoing routine IVF treatment. Objective: The objective of this study was to compare the efficacy of three types of progesterone on biochemical, clinical and ongoing pregnancy rates and abortion and live birth rates. Materials and Methods: A prospective randomized study was performed at Royan Institute between March 2008 and March 2009 in women under 40 years old, who use GnRH analog down-regulation. One hundred eighty six patients in three groups were received progesterone in oil (100 mg, IM daily), intravaginal progesterone (400 mg, twice daily) and 17-α hydroxyprogestrone caproate (375mg, every three days), respectively. Results: Final statistical analysis after withdrawal of some patients was performed in 50, 50 and 53 patients in group 1, 2 and 3 respectively. No differences between the groups were found in baseline characteristics. No statistical significance different was discovered for biochemical, clinical and ongoing pregnancies. Although the abortion rate was statistically higher in group 1 (p=0.025) the live birth rate was not statistically significant between the three groups. Conclusion: The effects of three types of progesterone were similar on pregnancies rate. We suggest the use of intravaginal progesterone during the luteal phase in patients undergoing an IVF-ET program because of the low numbers of abortions, and high ongoing pregnancy rates.


Related Articles

  • Evaluation of Endometrin as Luteal Phase Support. Feinberg, Eve C. // Fertility Weekly;3/4/2013, p1 

    The article presents the research conducted by state researchers in the U.S. regarding the use of endometrin as progesterone (P) in luteal support while maintaining high pregnancy rates (PRs) in autologous in vitro fertilization (IVF) cycles and donor oocyte cycles. It states that...

  • Comparison between two forms of vaginally administered progesterone for luteal phase support in assisted reproduction cycles. Geber, Selmo; Moreira, Ana Carolina Ferreira; De Paula, Sálua Oliveira Calil; Sampaio, Marcos // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Feb2007, Vol. 14 Issue 2, p155 

    The use of progesterone for luteal phase support has been demonstrated to be beneficial in assisted reproduction cycles using gonadotrophin-releasing hormone analogues (GnRHa). Two micronized progesterone preparations are available for vaginal administration: capsules and gel. The objective of...

  • Comparison of Methods of Luteal Phase Support.  // Fertility Weekly;12/24/2007, p1 

    The article discusses the study on luteal phase supplementation in stimulated in vitro fertilization (IVF) cycles. Accordingly, progesterone for luteal phase support (LPS) may be administered orally, vaginally and rectally. Moreover, a comparison of oral dydrogesterone (DG) was conducted with...

  • Estrogen addition to progesterone for luteal phase support in cycles stimulated with GnRH analogues and gonadotrophins for IVF: a systematic review and meta-analysis. E.M. Kolibianakis; C.A. Venetis; E.G. Papanikolaou; K. Diedrich; B.C. Tarlatzis; G. Griesinger // Human Reproduction;Jun2008, Vol. 23 Issue 6, p1346 

    BACKGROUND The purpose of the present systematic review and meta-analysis was to examine whether the probability of pregnancy is increased by adding estrogen to progesterone for luteal phase support in patients treated by in vitro fertilization (IVF). METHODS A literature search covering...

  • Effect of the Route of Progesterone Administration for Luteal Phase Support.  // Fertility Weekly;2/9/2009, p8 

    The article reports on the results of the research titled "Route of Progesterone Administration for Luteal Phase Support may Affect Outcome of Controlled Ovarian Hyperstimulation for IVF with ICSI Using GnRH Antagonist," by M. Bahceci and U. Ulug. They recommend the significance of the route of...

  • Ellios is Better Tolerated than Utrogestan.  // Fertility Weekly;3/18/2002, p16 

    The intravaginal daily application of Ellios is equivalent to Utrogestan administered vaginally in terms of supporting the luteal phase, however, side effects and subjective symptoms were different in two groups: the occurrence of vaginal discharge, drowsiness and pruritus were reported less...

  • 17α-Hydroxyprogesterone caproate versus intravaginal progesterone in IVF-embryo transfer cycles. Unfer, Vittorio; Casini, Maria Luisa; Costabile, Loredana; Gerli, Sandro; Baldini, Domenico; Di Renzo, G. C. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Jul2004, Vol. 9 Issue 1, p17 

    One of the main issues in the management of IVF and embryo transfer techniques is to ensure adequate concentrations of progesterone. The aim of this prospective, randomized study was to compare the effectiveness of 17α-hydroxyprogesterone caproate (17-HPC) administered intramuscularly and...

  • Vaginal gel versus intramuscular progesterone for luteal phase supplementation: a prospective randomized trial. Dal Prato, Luca; Bianchi, Liana; Cattoli, Monica; Tarozzi, Nicoletta; Flamigni, Carlo; Borini, Andrea // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Mar2008, Vol. 16 Issue 3, p361 

    The aim of this randomized study was to compare the efficacy of intramuscular progesterone (IMP) and progesterone in vaginal gel (VGP) at two different doses for luteal support in IVF. A total of 412 patients, aged between 28 and 37 years, were randomized into three groups. The day after oocyte...

  • Prospective randomized study comparing luteal phase support for ICSI patients up to the first ultrasound compared with an additional three weeks. Mohamed A. Aboulghar; Yahia M. Amin; Hesham G. Al-Inany; Mona M. Aboulghar; Latouna M. Mourad; Gamal I. Serour; Ragaa T. Mansour // Human Reproduction;Apr2008, Vol. 23 Issue 4, p857 

    BACKGROUND There is a consensus that administration of progesterone to women after IVF for luteal phase support (LPS) is associated with a higher ongoing pregnancy rate. However there are few studies, including only one randomized study, which have examined the optimal duration of LPS. METHODS...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics