Analysis of 232 total fertilization failure cycles during intracytoplasmic sperm injection

Sarikaya, Esma; Eryilmaz, Ozlem Gun; Ruya Deveer; Dogan, Muammer; Mollamahmutoglu, Leyla
April 2011
Iranian Journal of Reproductive Medicine;Spring2011, Vol. 9 Issue 2, p105
Academic Journal
Background: The intracytoplasmic sperm injection procedure ending with total fertilization failure is very distressfull event for both the clinician and the patient. Objective: The aim of this study was to identify independent factors which could be used to identify total fertilization failure before the day of intracytoplasmic sperm injection. Materials and Methods: This was a retrospective study of 232 patients who were admitted to a tertiary-care hospital IVF Unit and showed total fertilization failure during intracytoplasmic sperm injection cycles. To sort out the interwined effects of female age, basal FSH, sperm quality, antral follicle count, starting dose of gonadotrophine, sperm extraction technique, cycle length, >14 mm follicle number, oocyte number after oocyte pick up, estradiol and progesterone level on the day of hCG and the MI, MII and GV oocyte number on the fertilization, multiple logistic regression analysis was used. Results: The total fertilization failure rate was 6% and the recurrance rate was 23%. The original model illustrated that the presence of GV oocytes, total oocyte number less than six, <2000 pg/mL E2 concentration on the day of hCG and testicular sperm extraction increases the total fertilization failure risk. Conclusion: It is very difficult to predict total fertilization failure. Sometimes even with one good quality oocyte and sperm and in the case of globozoospermia fertilization can be achieved. Not only azoospermia but also low oocyte numbers increase the chance of total fertilization failure even after intracytoplasmic sperm injection.


Related Articles

  • Oocyte Electroactivation Improves Outcome.  // Fertility Weekly;1/19/2009, p9 

    The article reports on the findings of the study from Egypt on electrical activation of oocytes after intracytoplasmic sperm injection (ICSI) that improves fertilization rate. It notes that R. Mansour and colleagues made the study to determine whether electrical activation of oocytes is...

  • Coasting for Three Days Is Efficacious in Hyper-Responders.  // Fertility Weekly;5/1/2006, p2 

    This article presents the medical research entitled "Effect of Coasting on Cycle Outcome during In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles in Hyper-responders," by P. Kovacs and colleagues, published in the "Fertility & Sterility" periodical. The study is about determining...

  • In vitro maturation of human testicular sperm in patients with azoospermia. Zhu, Jianjun; Meniru, Godwin I. // Journal of Assisted Reproduction & Genetics;July97, Vol. 14 Issue 6, p361 

    Focuses on a method for maturing testicular sperm in vitro fertilization (IVF) in patients with azoospermia. Where the method was developed; Discussion on intracytoplasmic sperm injection (ICSI), microepididymal sperm aspiration (MESA) and percutaneous epididymal sperm aspiration (PESA).

  • Prognostic value of objective semen parameters in an in vitro fertilization program. Wittemer, Christiane; Warter, Stephanie // Journal of Assisted Reproduction & Genetics;July97, Vol. 14 Issue 6, p321 

    Presents the results of a study which examined the predictive value for success in in vitro fertilization (IVF) of three standard data of fresh semen and of objective parameters which test different functions, namely motility in fresh semen after treatment and the acrosomal reaction (AR). How...

  • Does Short Duration of Sperm-Oocyte Incubation Increase Viability of Embryos in Human In Vitro Fertilization? Lalic, Irena; Catt, James W.; Henman, Michael J.; Muir, Sally // Reproductive Technologies;Mar2001, Vol. 10 Issue 2, p062 

    Background: This study was conducted to clarify the conflicting reports of the benefits and disadvantages of decreasing the time of oocyte-sperm interaction in human in vitro fertilization (IVF). Methods: A controlled prospective study was undertaken on 502 IVF cases to determine if there was...

  • Submicroscopic mathematical evaluation of spermatozoa in assisted reproduction. 2. In vitro... Piomboni, P.; Strehler, E. // Journal of Assisted Reproduction & Genetics;Sep96, Vol. 13 Issue 8, p635 

    Studies the application of the Baccetti formula to in vitro fertilization (IVF). Correlation of the sperm submicroscopic characters in the formula with the result of IVF; Percentage of spermatozoa free from structural defects; Total number in the ejaculate spermatozoa free from defects.

  • Extracting sperm from testicles may help infertility. Wilson, Clare // New Scientist;7/13/2019, Vol. 243 Issue 3238, p10 

    The article reports on research regarding the use of sperm removed directly from the testicles for human in vitro fertilization.

  • Effects of Preservation of Mouse Spermatozoa in Electrolyte-Free Solution at 4 degrees Celsius on... Quan, Song; Yamano, Shuji // Journal of Assisted Reproduction & Genetics;Aug2000, Vol. 17 Issue 7, p389 

    Assesses the fertilizing capacity of spermatozoa cool-preserved in electrolyte-free (EF) solution. Comparison of the fertilizing capacity of mouse spermatozoa cool-preserved in EF with that of fresh spermatozoa; Impact of reinitiation procedure on the capacitated and acrosome-reacted...

  • Can Varying the Number of Spermatozoa Used for Insemination Improve In Vitro Fertilization Rates? Johnson, Jane E.; Boone, William R. // Journal of Assisted Reproduction & Genetics;Aug2000, Vol. 17 Issue 7, p397 

    Evaluates the effect of spermatozoal concentration on in vitro fertilization success. Relation of the increase in normal fertilization rates and the polypoid rates to the increase in the number of spermatozoa per oocyte; Reaction to the notion that an increase in spermatozoa may be toxic to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics