Detecting pre-diabetes and the role of the pharmacist

Simoens, Steven; de Coster, Sandra; Lenie, Jan; Hayen, Véronique; Laekeman, Gert
April 2011
Pharmacy Practice (18863655);Apr2011, Vol. 9 Issue 2, p88
Academic Journal
Objective: This study aims to use a pharmacoepidemiological approach to study the drug use of patients during the year prior to diabetes diagnosis (i.e. pre-diabetic patients) and control patients. Drug use might reveal cardiovascular, metabolic and/or endocrinological changes and help to identify indicators for active monitoring of Type 2 diabetes mellitus. Methods: A retrospective case-control study compared drug use of patients with a future diagnosis of diabetes (experimental patients) with patients without a diabetes diagnosis (control patients) based on community pharmacy records. An experimental patient had used oral hypoglycaemic drugs during 2005 or 2006. Experimental and control patients were matched in terms of age, gender and quarter of index date. Drugs were selected based on possible comorbidities of diabetes. Drug use was expressed as a binary variable, indicating whether or not a patient took specific drugs. Drug use was compared between experimental patients during the year prior to diagnosis and control patients using the chisquared test. Results: Our dataset covered 5,064 patients (1,688 experimental and 3,376 control patients). A higher probability of taking cardiovascular drugs was observed for specific subgroups of patients with prediabetes as compared to control patients: this trend was observed for men as well as for women, for various cardiovascular drug classes, and for different age groups (p<0.05), although it was not always statistically significant for the 29-38 age group. For each selected age and gender group, patients with pre-diabetes had a higher probability of taking a combination of a lipid-modifying agent and an antihypertensive drug than control patients (p<0.005). Conclusions: Using community pharmacy data, this study demonstrated that age and a characteristic drug use pattern could contribute to detecting pre-diabetes. There is a potential role for community pharmacists to follow up drug indicators of patients with a view to refer high-risk people for screening by a physician.


Related Articles

  • Trends in outpatient antibiotic use in Israel during the years 2000-2010: setting targets for an intervention. Low, M.; Nitzan, O.; Bitterman, H.; Cohen, C.; Hammerman, A.; Lieberman, N.; Raz, R.; Balicer, R. // Infection;Apr2013, Vol. 41 Issue 2, p401 

    Purpose: The abundant use of antibiotics (Abs) in the community plays a major role in inducing Ab resistance, but the literature concerning patterns in outpatient Ab use is limited. This study aims to lay the foundations for future policy and interventional programs to address the rise in Ab...

  • An observational study of psychotropic drug use and initiation in older patients resident in their own home or in care. Mccowan, Colin; Magin, Parker; Clark, Stella Anne; Guthrie, Bruce // Age & Ageing;Jan2013, Vol. 42 Issue 1, p51 

    Objective: to compare the prescription of psychotropic medications for patients living in care homes with that for patients living at home.Design and setting: retrospective population database study in the Tayside region of Scotland.Subjects: 70,297 patients aged ≥65 and followed until...

  • Study participation rate of patients with acute spinal cord injury early during rehabilitation. Krebs, J; Katrin Brust, A; Tesini, S; Guler, M; Mueller, G; Velstra, I-M; Frotzler, A // Spinal Cord;Oct2015, Vol. 53 Issue 10, p738 

    Study design:Retrospective observational study.Objectives:To investigate the study participation rate of patients with acute spinal cord injury (SCI) early during rehabilitation after conveying preliminary study information.Setting:Single SCI rehabilitation center in Switzerland.Methods:Newly...

  • Growth Impairment and Nutritional Status in Children with Chronic Kidney Disease. Sozeri, Betul; Mir, Sevgi; Kara, Orhan Deniz; Dincel, Nida // Iranian Journal of Pediatrics;Sep2011, Vol. 21 Issue 3, p271 

    Objective: Malnutrition is closely linked to chronic kidney disease (CKD) in adult patients with poor outcome. But data on pediatric patients is inadequate. The aim of this study was to describe the prevalence of growth failure and malnutrition in pediatric CKD patients and explore the...

  • Breastfeeding and introduction of complementary food in Danish infants. Kronborg, Hanne; Foverskov, Else; Væth, Michael // Scandinavian Journal of Public Health;Mar2015, Vol. 43 Issue 2, p138 

    Aim: The purpose of the present study was to describe early feeding patterns in Danish infants. Methods: A self-administered questionnaire was sent to 7113 mothers of newborns in the western part of Denmark approximately 6 months postpartum. A total of 5127 mothers (72%) returned the...

  • Trends in statin therapy initiation during the period 2000-2010 in Israel. Shalev, Varda; Weil, Clara; Raz, Raanan; Goldshtein, Inbal; Weitzman, Dahlia; Chodick, Gabriel // European Journal of Clinical Pharmacology;May2014, Vol. 70 Issue 5, p557 

    Purpose: The aim of this population-based study is to describe trends in the characteristics and treatment patterns of statin initiators over the first decade of the 21st century. Methods: New statin use was studied retrospectively using the database of Maccabi Healthcare Services (MHS), a large...

  • Pattern of triptan use and cardiovascular coprescription: a pharmacoepidemiological study in Italy. Biagi, Chiara; Poluzzi, Elisabetta; Roberto, Giuseppe; Puccini, Aurora; Vaccheri, Alberto; D'Alessandro, Roberto; Motola, Domenico; Montanaro, Nicola // European Journal of Clinical Pharmacology;Dec2011, Vol. 67 Issue 12, p1283 

    Purpose: We evaluated the incidence, prevalence, and patterns of triptan use with a special focus on patients who also received cardiovascular drugs, considered as a deviation from appropriate triptan use. Methods: We collected data on prescriptions reimbursed in between 2006 and 2008 in an...

  • Warfarin cessation is non-essential in patients undergoing total knee arthroplasty—a case-control study. Phillips, Alfred; Dan, Michael; Schaefer, Nathan; Randle, Raymond // Journal of Orthopaedic Surgery & Research;2015, Vol. 10 Issue 1, p1 

    Background: Warfarinised patients frequently present for total knee arthroplasty (TKA). Current practice of heparin ‘bridging' is potentially cumbersome and hazardous. The research question is if cessation of warfarin is necessary for TKA. Methods: The study design was a retrospective...

  • Inconsistent classification of pusher behaviour in stroke patients: a direct comparison of the Scale for Contraversive Pushing and the Burke Lateropulsion Scale. Bergmann, Jeannine; Krewer, Carmen; Rieß, Katrin; Müller, Friedemann; Koenig, Eberhard; Jahn, Klaus // Clinical Rehabilitation;Jul2014, Vol. 28 Issue 7, p696 

    The article focuses on the study which aims to compare the classification of two clinical scales for analyzing pusher behavior in a group of stroke patients. The study was conducted on 23 patients with hemiparesis caused by unilateral stroke and used interventions such as Scale for Contraversive...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics