TITLE

Antibiotic Treatment Strategies for Helicobacter pylori Infection

AUTHOR(S)
Campo, S. M. A.; Zullo, A.; Hassan, C.; Morini, S.
PUB. DATE
January 2007
SOURCE
Recent Patents on Anti-Infective Drug Discovery;Jan2007, Vol. 2 Issue 1, p11
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In the third decade of the Helicobacter pylori era several informations are available on its pathogenetic mechanisms, as well as on therapeutic approaches. A 7-14 day triple or quadruple regimens (proton pump inhibitor together with 2 antibiotics) are currently suggested as first-line treatment, but the success rate following these therapy is constantly decreasing worldwide. Therefore, new drugs are needed to treat such a widespread infection. Several patents of new antibiotics have been claimed in the last 5 years, and some of them showed a very powerful antibacterial activity in vitro, even against clarithromycin and metronidazole resistant strains. Among the new compounds, thienylthiazole derivatives, benzamide derivatives and pyloricidins should be regarded as very promising molecules.
ACCESSION #
64398998

 

Related Articles

  • Helicobacter pylori Treatment: A Practical Approach. Vakil, Nimish // American Journal of Gastroenterology;Mar2006, Vol. 101 Issue 3, p497 

    The treatment of Helicobacter pylori infection has become complicated by the lack of new treatment regimens and the emergence of drug resistant strains of H. pylori. Metronidazole and clarithromycin resistance are common in developed countries. Eradication rates have been falling in trials and...

  • Increase in Resistance Rates of H.pylori Isolates to Metronidazole and Tetracycline-Comparison of Three 3-Year Studies. Siavoshi, Farideh; Saniee, Parastoo; Lati-Navid, Saeid; Massarrat, Sadegh; Sheykholeslami, Arghavan // Archives of Iranian Medicine (AIM);May2010, Vol. 13 Issue 3, p177 

    Antimicrobials have been useful in the treatment of H.pylori-related dyspeptic diseases. However, emergence of resistant strains often decreases the eradication rates of H.pylori infections. Large-scale use of antimicrobials will lead to the diminishment of susceptible strains while allowing...

  • Past Antibiotic Use Affects Resistance and Outcomes of Helicobacter pylori Infection. Mcmahon, B.J.; Hennessy, T.W.; Bensler, J.M.; Bruden, D.L.; Parkinson, A.J.; Morris, J.M.; Reasonover, A.L.; Huriburt, D.A.; Bruce, M.G.; Sacco, F.; Butler, J.C. // Annals of Internal Medicine;9/16/2003, Vol. 139 Issue 6, pI10 

    Helicobacter pylori is a common type of bacteria that usually infects people during their childhoods. In most cases, the infection does not cause problems. However, some people with H. pylori infection get inflammation or ulcers in the stomach or upper intestine. Doctors treat inflammation and...

  • Previous Use of Macrolide Antibiotics Was Associated with Helicobacter pylori Resistance. McMahon, B. J.; Hennessy, T. W.; Bensler, J. M. // Annals of Internal Medicine;9/7/2004, Vol. 141 Issue 5, p374 

    This article presents information on Helicobacter (H) pylori infections. The investigators wanted to find out whether previous use of antibiotics would affect eradication rates of Helicobacter pylori infection. They retrospectively reviewed 125 patient records to identify antimicrobial agents...

  • Reality and false premises of antimicrobial susceptibility testing for Helicobacter pylori. Miwa, Hiroto; Sato, Nobuhiro // Journal of Gastroenterology;2003, Vol. 38 Issue 5, p519 

    Focuses on the antimicrobial susceptibility shown by the bacteria Helicobacter pylori. Resistance shown by the pylori strains towards clarithomycin; Relationship of metronidazole-resistant strains with the treatment failures; Influence of CAM resistance on the efficacy of proton pump inhibitor...

  • Emerging antimicrobial resistance pattern of Helicobacter pylori in central Gujarat. Pandya, H. B.; Agravat, Harihar Har; Patel, J. S.; Sodagar, NRK // Indian Journal of Medical Microbiology;Oct-Dec214, Vol. 32 Issue 4, p408 

    Background: Antimicrobial resistance is a growing problem in H. pylori treatment. The study was intended to evaluate the prevalence of resistance amongst 80 H.pylori isolates cultured from biopsy taken during routine endoscopies in 2008-2011. Materials and Methods: 855 gastro duodenal biopsies...

  • Efficacy of metronidazole for the treatment of clarithromycin-resistantHelicobacter pyloriinfection in a Japanese population. Shimoyama, Tadashi; Fukuda, Shinsaku; Mikami, Tatsuya; Fukushi, Michio; Munakata, Akihiro // Journal of Gastroenterology;2004, Vol. 39 Issue 10, p927 

    Background. Eradication of Helicobacter pylori has become a common treatment for several diseases. There is an increase in antibiotic-resistant strains, which causes the failure of eradication. The aim of this study was to investigate the usefulness of metronidazole for the treatment of H....

  • H pylori might protect children from asthma. Tanday, Sanjay // GP: General Practitioner;4/27/2007, p2 

    The article reports on the findings of the U.S. researchers who have discovered that Helicobacter (H) pylori might protect children from asthma. The findings suggest that giving antibiotics to children early in life might make them more susceptible to asthma by reducing levels of H pylori in the...

  • The Relationship among Previous Antimicrobial Use, Antimicrobial Resistance, and Treatment Outcomes for Helicobacter pylori Infections. Mcmahon, Brian J.; Hennessy, Thomas W.; Michael Bensler, J.; Bruden, Dana L.; Parkinson, Alan J.; Morris, Julie M.; Reasonover, Alisa L.; Huriburt, Debby A.; Bruce, Michael G.; Sacco, Frank; Butler, Jay C. // Annals of Internal Medicine;9/16/2003, Vol. 139 Issue 6, p463 

    Background: The relationship between previous antimicrobial treatments and infection with drug-resistant Helicobacter pylori is unknown. Objectives: To determine whether previous use of antimicrobial agents predicts subsequent antibiotic resistance of H. pylori and whether resistance affects...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics