Antibiotic Treatment Strategies for Helicobacter pylori Infection

Campo, S. M. A.; Zullo, A.; Hassan, C.; Morini, S.
January 2007
Recent Patents on Anti-Infective Drug Discovery;Jan2007, Vol. 2 Issue 1, p11
Academic Journal
In the third decade of the Helicobacter pylori era several informations are available on its pathogenetic mechanisms, as well as on therapeutic approaches. A 7-14 day triple or quadruple regimens (proton pump inhibitor together with 2 antibiotics) are currently suggested as first-line treatment, but the success rate following these therapy is constantly decreasing worldwide. Therefore, new drugs are needed to treat such a widespread infection. Several patents of new antibiotics have been claimed in the last 5 years, and some of them showed a very powerful antibacterial activity in vitro, even against clarithromycin and metronidazole resistant strains. Among the new compounds, thienylthiazole derivatives, benzamide derivatives and pyloricidins should be regarded as very promising molecules.


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