TITLE

Recent Patents on Melanoma with Focus on Genetic Strategies

AUTHOR(S)
Gramiccia, Talia; Saraceno, Rosita; Stefani, Alessandro D.; Chimenti, Sergio
PUB. DATE
June 2008
SOURCE
Recent Patents on Anti-Infective Drug Discovery;Jun2008, Vol. 3 Issue 2, p136
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Recent advances in molecular biology have enhanced the understanding of the pathology of melanocytic lesions. Several targetable pathways, responsible for survival and apoptosis resistance in melanoma cells, have been described and current research has focused on mechanism inactivating these pathways. However, the therapeutic resistance of malignant melanoma remains the main limit that cast the poor prognosis of cutaneous melanoma. Current advances in high-resolution genome-wide technologies, as well as gene-specific mutational analysis, in conjunction with genetic and phenotypic analyses, improved animal models, may ultimately help to better define the seminal molecular events contributing to disease pathogenesis and ultimately identify more effective therapeutic targets. The focus of this review is to summarize the emerging patents in the treatment and diagnosis of melanoma related to the latest genetic models and bio-molecular discoveries.
ACCESSION #
64398963

 

Related Articles

  • Sequence-based cancer genomics: progress, lessons and opportunities. Strausberg, Robert L.; Simpson, Andrew J. G.; Wooster, Richard // Nature Reviews Genetics;Jun2003, Vol. 4 Issue 6, p409 

    Technologies that provide a genome-wide view offer an unprecedented opportunity to scrutinize the molecular biology of the cancer cell. The information that is derived from these technologies is well suited to the development of public databases of alterations in the cancer genome and its...

  • My Life with Adeno-Associated Virus: A Long Time Spent Studying a Short Genome. Berns, Kenneth I. // DNA & Cell Biology;Jul2013, Vol. 32 Issue 7, p342 

    My 45 years of studying the molecular biology of adeno-associated virus are recounted. Additional activities as a mentor, department chair, and medical school administrator are described, as are my activities in the public sphere, which involved national issues related to science policy and...

  • Intelligibility in microbial complex systems: Wittgenstein and the score of life. Baquero, Fernando; Moya, Andrés // Frontiers in Cellular & Infection Microbiology;Jul2012, Vol. 2, p1 

    Knowledge in microbiology is reaching an extreme level of diversification and complexity, which paradoxically results in a strong reduction in the intelligibility of microbial life. In our days, the "score of life" metaphor is more accurate to express the complexity of living systems than the...

  • Interfering With Tumor Pathways That Augment Viral Oncolysis. Bell, John C // Molecular Therapy;Dec2011, Vol. 19 Issue 12, p2108 

    The author comments on a functional genomics approach that determines unexpected cancer-specific pathways which can augment oncolytic virus (OV) killing of tumor cells. He says that major breakthroughs in the understanding of the molecular biology of the cell has been led by studying viruses....

  • Structure determination of genomic domains by satisfaction of spatial restraints. Baù, Davide; Marti-Renom, Marc // Chromosome Research;Jan2011, Vol. 19 Issue 1, p25 

    The three-dimensional (3D) architecture of a genome is non-random and known to facilitate the spatial colocalization of regulatory elements with the genes they regulate. Determining the 3D structure of a genome may therefore probe an essential step in characterizing how genes are regulated....

  • Advances in genomic characterization of circulating tumor cells. Magbanua, Mark; Park, John // Cancer & Metastasis Reviews;Sep2014, Vol. 33 Issue 2/3, p757 

    Molecular characterization of circulating tumor cells (CTCs) found in the blood of cancer patients offers the potential to provide new insights into the biology of cancer metastasis. However, since they are rare and difficult to isolate, the molecular nature of CTCs remains poorly understood. In...

  • Genomic discovery and the medical market: What does the future hold? Hammond, John B.W. // International Journal of Medical Marketing;Jan2002, Vol. 2 Issue 2, p167 

    Focuses on the changes in product type for the medical market. Achievements and promises of the genome, genome-associated and other molecular biology projects; Application of human genome project data; Major impacts of genomic sequencing programs on molecular biology; Products that can be...

  • Little and large.  // Nature Genetics;Feb2001, Vol. 27 Issue 2, p127 

    Editorial. Comments on the status of the human genome project. Significance to the medical community; Scientific and medical implications of the project; Role of molecular biology in the so-called big science era.

  • Big genome ? big science?  // Nature Cell Biology;Mar2001, Vol. 3 Issue 3, pE65 

    Editorial. Focuses on the significance of human genome in understanding of human evolution, physiology and disease. Efforts of molecular cell biologists to use human genome for cell functions; Potentials of human genome in scientific discovery; Analysis of computational approaches to deal with...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics