TITLE

Cardiovascular MRI in clinical trials: expanded applications through novel surrogate endpoints

AUTHOR(S)
Pitcher, Alex; Ashby, Deborah; Elliott, Paul; Petersen, Steffen E
PUB. DATE
August 2011
SOURCE
Heart;Aug2011, Vol. 97 Issue 16, p1286
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Recent advances in cardiovascular magnetic resonance (CMR) now allow the accurate and reproducible measurement of many aspects of cardiac and vascular structure and function, with prognostic data emerging for several key imaging biomarkers. These biomarkers are increasingly used in the evaluation of new drugs, devices and lifestyle modifications for the prevention and treatment of cardiovascular disease. This review outlines a conceptual framework for the application of imaging biomarkers to clinical trials, highlights several important CMR techniques which are in use in randomised studies, and reviews certain aspects of trial design, conduct and interpretation in relation to the use of CMR.
ACCESSION #
64373447

 

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