Molecular Basis for Some Disorders of Haemoglobin Synthesis—I*

Weatherall, D. J.
November 1974
British Medical Journal;11/23/1974, Vol. 4 Issue 5942, p451
Academic Journal
No abstract available.


Related Articles

  • Thalassaemia: the long road from bedside to genome. Weatherall, David J. // Nature Reviews Genetics;Aug2004, Vol. 5 Issue 8, p625 

    The evolution of research into inherited haemoglobin disorders posed some fascinating questions for historians of the medical sciences in the twentieth century. Of particular interest is how the study of what initially seemed to be a group of rare genetic anaemias turned out to be the forerunner...

  • New insights into the genetics of congenital neutropenia. Özbek, Namik // Turkish Journal of Hematology;Mar2009, Vol. 26 Issue 1, p1 

    Several congenital disorders may cause neutropenia. The recent advances in the field of molecular biology have facilitated our knowledge concerning pathophysiological mechanisms leading to these disorders. The molecular basis of disorders with defective myelopoiesis (severe congenital...

  • Total Extraction as a Treatment for Anaemia in a Patient of Glanzmann's Thrombasthenia with Chronic Gingival Bleed: Case Report. GHOSH, ABHISHEK; KUMAR, SAURABH; CHACKO, RABIN; CHARLU, ARUN PAUL // Journal of Clinical & Diagnostic Research;Jan2016, Vol. 10 Issue 1, p11 

    Glanzmann's Thrombasthenia (GT) is a rare autosomal recessive bleeding disorder affecting the megakaryocyte lineage and is characterized by lack of platelet aggregation on stimulation. The molecular basis is linked to quantitative and qualitative abnormalities of aIIbß3 integrin. Most of the...

  • Prevalence and molecular basis of α thalassaemia in British South Asians. Hassall, O. W.; Tillyer, M. L.; Old, J. M. // Journal of Medical Screening;Mar1998, Vol. 5 Issue 1, p31 

    Objectives To determine the prevalence and molecular basis of α thalassaemia in the British South Asian population, and the implications for genetic screening for haemoglobin disorders. Methods 397 South Asian subjects were screened for haemoglobinopathy with measurement of full blood count,...

  • Diagnostic applications of newborn screening for α-thalassaemias, haemoglobins E and H disorders using isoelectric focusing on dry blood spots. Jindatanmanusan, Punyanuch; Riolueang, Suchada; Glomglao, Waraporn; Sukontharangsri, Yaowapa; Chamnanvanakij, Sangkae; Torcharus, Kitti; Viprakasit, Vip // Annals of Clinical Biochemistry;Mar2014, Vol. 51 Issue 2, p237 

    The article discusses a study on diagnostic application of newborn screening associated with haemoglobin (Hb) E and H disorders and α-thalassaemias using isoelectric focusing (IEF) on dry blood spots. Among the topics include neonatal screening for Hb disorders, thalassaemia syndrome, and...

  • Recent Literature. Harper, Peter S. // Human Genetics;Jun2003, Vol. 113 Issue 1, p96 

    Reviews books on genetics. "Genetics for Orthopedic Surgeons: The Molecular Genetic Basis of Orthopedic Disorders," by Ian D. Young; "Genetics for Cardiologists: The Molecular Genetic Basis of Cardiovascular Disorders," by Ali J. Marian; "Genetics for Hematologists: The Molecular Genetic Basis...

  • Inheritance of Hereditary Persistence of Fetal Haemoglobin (HPFH) in a Family of Western Odisha, India. PATEL, SIRIS; DEHURY, SNEHADHINI; PUROHIT, PRASANTA; MEHER, SATYABRATA; DAS, KISHALAYA // Journal of Clinical & Diagnostic Research;Sep2015, Vol. 9 Issue 9, p9 

    Hereditary persistence of foetal haemoglobin (HPFH) is a rare inherited haemoglobin disorders in India. We encountered five cases of HPFH-3 in heterozygous condition in a single family of western Odisha, India. All the cases had raised % HbF (26.1±3.23%) with pancellular distribution of HbF...

  • Sickle cell disease in surgery. Mutiso, Vincent Muoki; Ongaro, N. // Tropical Doctor;Oct2006, Vol. 36 Issue 4, p200 

    The article deals with sickle cell disease, a group of related genetic disorders caused by the presence of abnormal sickle haemoglobin. It is characterized by the homozygous form of the disease, in which some are with the disease and some are carriers of the disease. The sickle cell disease is a...

  • Epidemiological evidence and molecular basis of interactions between HIV and JC virus. Berger, Joseph R.; Chauhan, Ashok; Galey, David; Nath, Avi // Journal of NeuroVirology;Aug2001, Vol. 7 Issue 4, p329 

    Focuses on epidemiological evidence and molecular basis of interactions between HIV and JC virus. Immunosuppressive conditions in lymphoproliferative disorders.

  • Genetics for Cardiologists: The Molecular Genetic Basis of Cardiovascular Disorders. Samani, N. J. // Journal of Medical Genetics;Jun2002, Vol. 39 Issue 6, p454 

    Reviews the book "Genetics for Cardiologists: The Molecular Genetic Basis of Cardiovascular Disorders," by Ali J. Marian.


Read the Article

Other Topics