Phenacetin Nephropathy, with Particular Reference to the Effect of Surgery

Koutsaimanis, K. G.; de Wardener, H. E.
October 1970
British Medical Journal;10/18/1970, Vol. 4 Issue 4728, p131
Academic Journal
No abstract available.


Related Articles

  • Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice. Peters, Jeffrey M.; Morishima, Hideki; Ward, Jerrold M.; Coakley, Christopher J.; Kimura, Shioko; Gonzalez, Frank J. // Toxicological Sciences;Jul1999, Vol. 50 Issue 1, p82 

    The mechanisms underlying phenacetin-induced toxicity and carcinogenicity are not clear. In particular, it is not known whether these effects are mediated by metabolic activation of the drug. CYP1A2 is known to metabolize phenacetin in vitro. To determine the role of this enzyme in vivo, the...

  • The origins of analgesic nephropathy. Murray, Robin M.; Murray, R M // British Journal of Psychiatry;Jul73, Vol. 123 Issue 572, p99 

    The article presents a study on the origin and history of analgesic nephropathy in Glasgow, Scotland. The study assesses the association between renal papillary necrosis and prolonged ingestion of compound analgesics containing aspirin and phenacetin. The frequent symptoms of patients with...

  • Renal papillary necrosis after aspirin and alclofenac. Gokal, R.; Matthews, D.R. // British Medical Journal;12/10/1977, Vol. 2 Issue 6101, p1517 

    Examines the association between renal papillary necrosis and long-term analgesic consumption. Determination of toxic components of phenacetin; Etiology of analgesic nephropathy; Components of alclofenac.

  • The Origins of Analgesic Nephropathy. Murray, Robin M. // British Journal of Psychiatry;Dec72, Vol. 121 Issue 565, p680 

    The article presents the abstract of the study "The Origins of Analgesic Nephropathy." It examines fifty-one Scottish patients who are suffering from renal failure due to abuse of analgesic. The findings show that Askit and codeine compound were the main drugs abused, while the average amount of...

  • The Nephrotoxicity of Analgesic Abuse. Schreiner, George E. // Annals of Internal Medicine;Dec62, Vol. 57 Issue 6, p1047 

    Editorial. Examines the nephrotoxicity of analgesic abuse. Association between the abuse of phenacetin and renal disease; Mechanism for induction of secondary tubular damage; Effect of phenacetin nephrotoxic on the cells of renal parenchyma.

  • Analgesic nephropathy: is it caused by multi-analgesic abuse or single substance use? Elseviers, M.M.; de Broe, M.E. // Drug Safety;Jan1999, Vol. 20 Issue 1, p15 

    Analgesic nephropathy is a slowly progressive renal disease, characterised by renal papillary necrosis. Recently, diagnostic criteria for this disease have been defined based on renal computed tomography scanning performed without contrast. The observation of a decreased renal mass of both...

  • Renoprotective effect of enalapril in diabetic patients. Nuovo, Jim // American Family Physician;6/1/1998, Vol. 57 Issue 11, p2826 

    Presents information pertaining to the long-term effects of diabetes which have been poorly controlled with reference to the condition known as diabetic nephropathy. Information on the angiotensin converting enzyme (ACE) inhibitors; Reference to the diabetic nephropathy not being cured.

  • THE EFFECT OF METHANOL ON SERUM PHENACETIN CONCENTRATION IN THE RAT. Łukasik, Marcin; Szutowski, Mirosław M.; Makarewicz, Marta // Acta Toxicologica;2007, Vol. 15 Issue 1, p31 

    Introduction: The absorption process is an essential stage that determines the bioavailability of xenobiotics during extravascular administration. The intensity of absorption depends on numerous factors not necessarily related to the substance and its formulation, and also on biotransformation...

  • Renal complications of B-cell dyscrasias. Gallo, G. // New England Journal of Medicine;6/27/91, Vol. 324 Issue 26, p1889 

    Editorial. Discusses renal complications of B-cell dyscrasias, particularly the deposition of monoclonal immunoglobulins. Refers to the study by Solomon et al, in this issue of the `New England Journal of Medicine.' Bence Jones cast nephropathy; Albuminuria.

  • Analgesic Nephropathy. Kincaid-Smith, Priscilla // Annals of Internal Medicine;Apr68, Vol. 68 Issue 4, p949 

    Editorial. Deals with the controversy concerning the effect of analgesics on the kidneys. Clinical features of analgesic abuse that warrant further comment; Factors which make it difficult accepting that analgesics cause kidney damage; Effect of salicylates, paracetamol and phenacetin on the...


Other Topics