Formulation and evaluation of gum based matrix tablets of Lamivudine

Apparao, Potu; Prabhakarreddy, Veerareddy; Raju, Jukanti; Shashidher, Burra
June 2011
Der Pharmacia Sinica;2011, Vol. 2 Issue 3, p176
Academic Journal
The present investigation is aimed at formulating and evaluating gum based sustained release matrix tablets of Lamivudine using different natural polymers such as Guar gum, Xanthan gum, Rosin gum, Pectin, and Sodium alginate taken at 30%, 40% and 50% of the total weight of the tablet. Lamivudine is a potent hydrophilic anti viral agent indicated for treatment of AIDS (Acquired Immunodeficiency Syndrome). It was found that the cumulative percent drug release decreased with increasing concentration of natural gums. All the formulations were able to retard the release of the drug beyond 18 hours except pectin and sodium alginate were unable to sustain the drug release from the matrix tablets. F5 (40% Xanthan Gum) formulation was selected as optimized formulation. The swelling study states that the swelling index was increased up to 6 hours and there after that the swelling index was decreased. No chemical interaction between Drug and the gum were seen as confirmed by FT-IR studies. Thus, sustained release matrix tablets of Lamivudine using natural Biodegradable and biocompatible polymers were successfully formulated, evaluated and found to be suitable candidates in extending the release of the drug from the matrix tablets.


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