Editorial: Pathogenesis of emphysema
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Editorial. Comments on a study which discussed the protease theory of the pathogenesis of emphysema. Development of the theory; Relevance of the theory in the acquired form of emphysema; Clinical implications of the study.
- Medicine: Smoke signals for lung disease. Roberts, Anita B. // Nature;3/13/2003, Vol. 422 Issue 6928, p130
Discusses the identification of a group of proteins that might confer susceptibility to emphysema. Significance of the discovery of transforming growth factor as one of the proteins; Pathogenesis of the airflow restriction in emphysema; Investigation of the gene for the matrix metalloproteinase...
- Progress in Research in Emphysema and Chronic Bronchitis (Book). Kuschner, Marvin // Annals of Internal Medicine;Jan66, Vol. 64 Issue 1, p222
Reviews the book 'Progress in Research in Emphysema and Chronic Bronchitis. The Pathogenesis of the Chronic Obstructive Bronchopulmonary Diseases,' edited by Roger S. Mitchell.
- Postoperative orbital emphysema in a patient with nasoorbitoethmoidal fracture: case report. Tuncer, Serdar; G&üven, Erdem; Emekli, Ufuk; Kesim, Sinan Nur // European Journal of Plastic Surgery;Apr2005, Vol. 28 Issue 1, p46
Reports on the case of unilateral orbital emphysema occurring as a result of forced hyperventilation that was used after extubation to treat laryngospasm in a patient with panfacial fractures. Male patient involved in a motor vehicle accident; Pathogenesis, prevention and management of orbital...
- Surgery for Emphysema. Mintz, Jim // New England Journal of Medicine;3/14/2002, Vol. 346 Issue 11, p860
A letter to the editor is presented related to lung-volume reduction surgery for emphysema in reference to the National Emphysema Treatment Trial (NETT) report and an accompanying editorial by Jeffrey M. Drazen.
- The role of collagenase in emphysema. Foronjy, Robert; D'Armiento, Jeanine // Respiratory Research;2001, Vol. 2, p348
The extracellular matrix is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to an imbalance in the proteases and antiproteases within the lung. Studies have focused on elastolytic...
- Lipid let loose in pulmonary emphysema. Elias, Jack A.; Chun Geun Lee // Nature Medicine;May2005, Vol. 11 Issue 5, p471
Discusses the finding that the lipid mediator ceramide contributes to tissue destruction in emphysema by promoting apoptosis of structural cells in the lung, which challenges a traditional hypothesis for the pathogenesis of emphysema and chronic bronchitis. Hypothesis that cellular injury that...
- Antibiotic Management in Patients with Chronic Bronchitis and Emphysema. // Annals of Internal Medicine;Dec72, Vol. 77 Issue 6, p993
Editorial. Discusses the roles of bronchopulmonary infection in the development and course of chronic bronchitis and emphysema. Association between severe hereditary alpha[sub1] -antitrypsin deficiency and pulmonary emphysema; Recommendations for patients with recurrent exacerbations of...
- Chronic obstructive pulmonary disease · 3: Experimental animal models of pulmonary emphysema. Mohadeva, R.; Shapiro, S. D. // Thorax;Oct2002, Vol. 57 Issue 10, p908
Animal studies have been critical in shaping contemporary views regarding the pathogenesis of emphysema. The intratracheal instillation of the plant proteinase papain into rats resulted in emphysema. Intrapulmonary challenge with injurious proteins, chemicals, particulates, and other compounds...
- Prothymosin ? overexpression contributes to the development of pulmonary emphysema. Su, Bing-Hua; Tseng, Yau-Lin; Shieh, Gia-Shing; Chen, Yi-Cheng; Shiang, Ya-Chieh; Wu, Pensee; Li, Kuo-Jung; Yen, Te-Hsin; Shiau, Ai-Li; Wu, Chao-Liang // Nature Communications;May2013, Vol. 4 Issue 5, p1906
Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin ? transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin ? in emphysema remains unclear. Here we show that prothymosin ? contributes to the...
