Genetic Control of Phenylbutazone Metabolism in Man

Whittaker, J. A.; Evans, D. A. Price
November 1970
British Medical Journal;11/7/1970, Vol. 4 Issue 5731, p323
Academic Journal
No abstract available.


Related Articles

  • Phenylbutazone overdosage: abnormal metabolism associated with hepatic and renal damage. Prescott, L.F.; Critchley, J.A.J.H.; Balali-Mood, M. // British Medical Journal;10/25/1980, Vol. 281 Issue 6248, p1106 

    Evaluates the complications of phenylbutazone overdosage. Correlation between abnormal metabolism and hepatic and renal damage; Details of a case of overdosage of a girl; Manifestation of high concentration of hydroxyphenylbutazone in the drug.

  • Drugs and Genes. Motulsky, Arno G. // Annals of Internal Medicine;Jun69, Vol. 70 Issue 6, p1269 

    Editorial. Comments on the genetic aberrations in drug pathway metabolism. Discussion on the concepts of pharmacokinetics; Genetic control of isoniazid inactivation; Significance of biochemical mechanisms in drug metabolism.

  • Clinical and Genetic Aspects of Coagulopathies. Koller, Fritz // Annals of Internal Medicine;Apr65, Vol. 62 Issue 4, p744 

    Focuses on the clinical and genetic aspects of blood coagulation disorders. Deficiency of clotting factors in hereditary and acquired coagulopathies; Hemophilia in royal families in Europe; Potentiation of anticoagulant effect of dicoumarol derivative by phenylbutazone.

  • Dipyrone/phenylbutazone.  // Reactions Weekly;4/24/2010, Issue 1298, p16 

    The article describes the case of a 50-year-old man who acquired neutropenia and necrotising fascilitis following intake of Jamu Pega Linu, an Asian medication, which was tainted with dipyrone and phenylbutazone.

  • Non-Classical Drug Metabolism Enzymes: The Curious Case of Phenylalanine 4-Monooxygenase. Steventon, G. B.; Mitchell, S. C. // Letters in Drug Design & Discovery;Aug2006, Vol. 3 Issue 6, p405 

    Phenylalanine 4-monooxygenase is a hepatic enzyme that controls the rate of catabolism of Lphenylalanine in man. Genetic defects in the phenylalanine 4-monooxygenase gene are known to be the cause of the majority of cases of phenylketonuria and these defects are now well characterized at the DNA...

  • Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance. Baron, Matthew G.; Mintram, Kate S.; Owen, Stewart F.; Hetheridge, Malcolm J.; Moody, A. John; Purcell, Wendy M.; Jackson, Simon K.; Jha, Awadhesh N. // PLoS ONE;1/3/2017, Vol. 12 Issue 1, p1 

    At high internal doses, pharmaceuticals have the potential for inducing biological/pharmacological effects in fish. One particular concern for the environment is their potential to bioaccumulate and reach pharmacological levels; the study of these implications for environmental risk assessment...

  • Ethics of Manipulation: Issues in Medicine, Behavior Control and Genetics/Premeditated Man: Bioethics and the Control of Future Human Life. JONSEN, ALBERT R. // America;4/24/1976, Vol. 134 Issue 16, p368 

    The article reviews "Ethics of Manipulation: Issues in Medicine, Behavior Control & Genetics," by Bernard Haring and "Premeditated Man: Bioethics & the Control of Future Human Life," by Richard Restak.

  • PHENYLBUTAZONE HEPATITIS. Ecker, Jerome A. // American Journal of Gastroenterology;Jan1965, Vol. 43 Issue 1, p23 

    Presents a case report on the incidence of phenylbutazone hepatitis. Description of phenylbutazone hepatitis; Etiology and mechanism; Classification of toxic liver disease.

  • Three Genetic Polymorphisms of Homocysteine-Metabolizing Enzymes and Risk of Coronary Heart Disease: Appraisal of a Recent Meta-Analysis. Pan, Feng; Tian, Jing; Zhang, Ying; Pan, Yueyin // DNA & Cell Biology;Feb2012, Vol. 31 Issue 2, p135 

    A letter to the editor is presented in response to the article "Three Genetic Polymorphisms of Homocysteine- Metabolizing Enzymes and Risk of Coronary Heart Disease: A Meta-Analysis Based on 23 Case-Control Studies," that was published in the previous issue.

  • Meta-Analysis Discovers New Genes Affecting Cholesterol Levels. Hobbs, Heather // International Labmate;Jun2015, Vol. 40 Issue 4, p6 

    The article focuses on researchers at FIMM (Institute for Molecular Medicine Finland) and University of Helsinki have discovered after studying genome information that genetic variants impact cholesterol metabolism and states this information helps in controlling cardiovascular diseases.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics