Tropical Splenomegaly Syndrome: Long-term Proguanil Therapy Correlated with Spleen Size, Serum IgM, and Lymphocyte Transformation

Sagoe, Aba-Segua
August 1970
British Medical Journal;8/15/1970, Vol. 3 Issue 5719, p378
Academic Journal
No abstract available.


Related Articles

  • Assessment of immune cells and function of the residual spleen after subtotal splenectomy due to splenomegaly in cirrhotic patients. Hai-Bo Chu; Ting-Guo Zhang; Jian-Hua Zhao; Feng-Guo Jian; Yong-Bo Xu; Tao Wang; Min Wang; Jin-Yuan Tang; Hong-Jie Sun; Kun Li; Wen-Jun Guo; Xiao-Ji Zhu // BMC Immunology;2014, Vol. 15 Issue 1, p1 

    Background The spleen is thought to be central in regulating the immune system, a metabolic asset involved in endocrine function. Overwhelming postsplenectomy infection leads to a mortality rate of up to 50%. However, there is still controversy on performing subtotal splenectomy as treatment of...

  • Histological and immunohistochemical features of the spleen in persistent polyclonal B-cell lymphocytosis closely mimic splenic B-cell lymphoma. Ping Sun; Juskevicius, Ridas // Diagnostic Pathology;2012, Vol. 7 Issue 1, p107 

    Persistent polyclonal B-cell lymphocytosis (PPBL) is rare and intriguing hematological disorder predominantly reported in young to middle- aged smoking women. It is characterized by persistent moderate polyclonal B-cell lymphocytosis with circulating hallmark binucleated lymphocytes and elevated...

  • Clinical characteristics and factors predicting evolution of asymptomatic IgM monoclonal gammopathies and IgM-related disorders. Morra, F.; Cesana, C.; Klersy, C.; Barbarano, L.; Varettoni, M.; Cavanna, L.; Canesi, B.; Tresoldi, F.; Miqueleiz, S.; Bernuzzi, P.; Nosari, A.M.; Lazzarino, M. // Leukemia (08876924);Sep2004, Vol. 18 Issue 9, p1512 

    We evaluated the prognostic features of 384 asymptomatic IgM-monoclonal gammopathies (aIgM-MGs) and 74 IgM-related disorders (IgM-RDs), two clinically distinct groups as proposed by the Second International Workshop on Waldenström's Macroglobulinemia (WM). The cumulative probability of...

  • A Case of Hyper-reactive Malarial Splenomegaly. The Role of Rapid Antigen-detecting and PCR-based Tests. Mothe, B.; Lopez-Contreras, J.; Torres, O.; Muñoz, C.; Domingo, P.; Gurgui, M. // Infection;Apr2008, Vol. 36 Issue 2, p167 

    Hyper-reactive malarial splenomegaly (HMS) – originally referred to as tropical splenomegaly syndrome – is characterized by a massive splenomegaly, high titres of anti-malarial antibodies and polyclonal IgM hypergammaglobulinemia. It is believed to be a consequence of an aberrant...

  • The hyper-reactive malarial splenomegaly: a systematic review of the literature. Leoni, Stefania; Buonfrate, Dora; Angheben, Andrea; Gobbi, Federico; Bisoffi, Zeno // Malaria Journal;2015, Vol. 14 Issue 1, p1 

    Background: The hyper-reactive malarial splenomegaly syndrome (HMS) is a leading cause of massive splenomegaly in malaria-endemic countries. HMS is caused by a chronic antigenic stimulation derived from the malaria parasite. Classic Fakunle's major criteria for case definition are: persistent...

  • Obscure splenomegaly in the tropics that is not the tropical splenomegaly syndrome. DeCock, Kevin M.; Lucas, S.B.; Rees, P.H.; Hodgen, A.N.; Jupp, R.A.; Slavin, B. // British Medical Journal (Clinical Research Edition);11/5/1983, Vol. 287 Issue 6402, p1347 

    Examines the undiagnosed tropical splenomegaly syndrome in patients. Criteria for the diagnosis; Analysis on the etiological relevance of malaria; Difficulty in the diagnosis of tropical splenomegaly syndrome by exclusion.

  • Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients. Alkadarou, Tayseer; Musa, Ahmed; Alkadarou, Abedelgader; Mahfouz, Mohamed S.; Troye-Blomberg, Marita; Elhassan, Ahmed M.; Elhassan, Ibrahim M. // Journal of Tropical Medicine (16879686);2013, p1 

    Hyperreactive Malarial Splenomegaly (HMS) is defined as a massive enlargement of the spleen resulting from abnormal immune responses after repeated exposure to the malaria parasites. This study was carried out in Khartoum, Sudan. Sudan is considered to be one of the countries where HMS is quite...

  • Proliferative glomerulonephritis with monoclonal IgM deposits without Waldenstr�m's macroglobulinemia: case report and review of the literature. Yahata, Mayumi; Nakaya, Izaya; Takahashi, Satoko; Sakuma, Tsutomu; Sato, Hiroshi; Soma, Jun // Clinical Nephrology;Mar2012, Vol. 77 Issue 3, p254 

    A 38-year-old man was presented with nephrotic syndrome associated with hematuria and mild hypocomplementemia. Renal biopsy revealed lobular mesangial proliferation, thickened capillary walls, and intraluminal protein thrombi. Immunofluorescence showed marked and mild depositions of...

  • Hiperimmünglobulin M Sendromu. Üner, Gülcan; Çekiç, Şükrü; Gültekin, Sara Şebnem Kılıç // Journal of Current Pediatrics / Guncel Pediatri;8/1/2014, Vol. 12 Issue 2, p81 

    Hyperimmunoglobulin M syndrome is a primary immune deficiency characterized by increased or normal levels of serum IgM with clearly decreased serum IgG, IgA and IgE levels. Patients affected with hiper IgM syndrome are susceptible to recurrent pyogenic infections, to autoimmune diseases induced...

  • Normal dalak ile splenomegalinin karşılaÅŸtırılması ve vücut kompozisyonu ile iliÅŸkileri. Çağlar, Veli; Alkoç, Ozan Alper; Uygur, Ramazan; Tuğtağ, Berrin; Özçağlayan, Ömer // Genel Tip Dergisi;2014, Vol. 24 Issue 2, p64 

    Objective: To compare spleen sizes between healthy individuals and individuals diagnosed with splenomegaly, and to determine the effect of body composition on spleen size. Material and methods: Computed tomography images were obtained retrospectively from Radiology Department of Namik Kemal...


Read the Article

Other Topics