Recurrent infection and deficiency of complement

June 1970
British Medical Journal;6/27/1970, Vol. 2 Issue 5712, p744
Academic Journal
No abstract available.


Related Articles

  • Relapsing Neisseria meningitidis Infection Associated with C8 Deficiency. Liston, Thomas E. // Clinical Pediatrics;Sep1983, Vol. 22 Issue 9, p605 

    Infection due to serogroup Y of Neisseria meningitidis has many clinical manifestations, ranging from mild bacteremia to fatal sepsis and meningitis. N. meningitidis infection may coincide with several complement deficiencies. A child is described who suffered from recurrent disease due to N....

  • Renal disease associated with inherited disorders of the complement system. Welch, Thomas R.; Blystone, Lisa W. // Pediatric Nephrology;Aug2009, Vol. 24 Issue 8, p1439 

    The human complement system is vital for host defense and plays a role in a number of inflammatory disorders. Inherited deficiency or dysfunction of most of the individual complement components occurs uncommonly. The phenotype displayed by such patients varies with the specific component...

  • Complement. Walport, Mark J. // New England Journal of Medicine;04/05/2001, Vol. 344 Issue 14, p1058 

    Presents a review organized around the three main associations between complement and disease. Role of complement in the immune system; Complement deficiency and susceptibility to infection; Consequences of abnormalities in the regulation of the complement system; Role of complement deficiency...

  • An Infantile Case of Early Manifestation of SLE-like Symptoms in Complete C1q Deficiency. Hayakawa, Jun; Migita, Makoto; Ueda, Takahiro; Itoh, Yasuhiko; Fukunaga, Yoshitaka // Journal of Nippon Medical School;2011, Vol. 78 Issue 5, p322 

    C1q deficiency is a rare complement deficiency in the early part of the complement cascade. Patients with C1q deficiency have severe recurring life-threatening infections and systemic lupus erythematosus (SLE)-like symptoms. We report on a boy with recurrent lifethreatening infections and...

  • Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases. Martini, Paolo G. V.; Cook, Lynette C.; Alderucci, Scott; Norton, Angela W.; Lundberg, Dianna M.; Fish, Susan M.; Langsetmo, Knut; Jönsson, Göran; Lood, Christian; Gullstrand, Birgitta; Zaleski, Kate J.; Savioli, Nancy; Lottherand, Jason; Bedard, Charles; Gill, John; Concino, Michael F.; Heartlein, Michael W.; Truedsson, Lennart; Powell, Jan L.; Tzianabos, Arthur O. // BMC Immunology;2010, Vol. 11, p43 

    Background: Complement C2 deficiency is the most common genetically determined complete complement deficiency and is associated with a number of diseases. Most prominent are the associations with recurrent serious infections in young children and the development of systemic lupus erythematosus...

  • Meningococcal disease and the complement system. Lewis, Lisa A; Ram, Sanjay // Virulence;Jan2014, Vol. 5 Issue 1, p98 

    Despite considerable advances in the understanding of the pathogenesis of meningococcal disease, this infection remains a major cause of morbidity and mortality globally. The role of the complement system in innate immune defenses against invasive meningococcal disease is well established....

  • Classical and Non-classical Presentations of Complement Factor I Deficiency: Two Contrasting Cases Diagnosed via Genetic and Genomic Methods. Shields, Adrian M.; Pagnamenta, Alistair T.; Pollard, Andrew J.; Taylor, Jenny C.; Allroggen, Holger; Patel, Smita Y.; Knight, Samantha J. L.; Popitsch, Niko; Camps, Carme; Pentony, Melissa M.; Kvikstad, Erika M.; Lange, Lukas; Hashim, Mona; Harris, Steve; Tilley, Mark; Vavoulis, Dimitris; Kaisaki, Pamela; Ragoussis, Vassilis; Feral, Matteo; Schuh, Anna H. // Frontiers in Immunology;6/7/2019, pN.PAG 

    Deficiency of complement factor I is a rare immunodeficiency that typically presents with increased susceptibility to encapsulated bacterial infections. However, non-infectious presentations including rheumatological, dermatological and neurological disease are increasingly recognized and...

  • Immunodeficiency Associated with FCN3 Mutation and Ficolin-3 Deficiency. Munthe-Fog, Lea; Hummelsh�j, Tina; Honor�, Christian; Madsen, Hans O.; Permin, Henrik; Garred, Peter // New England Journal of Medicine;6/18/2009, Vol. 360 Issue 25, p2637 

    Ficolin-3, encoded by the FCN3 gene and expressed in the lung and liver, is a recognition molecule in the lectin pathway of the complement system. Heterozygosity for an FCN3 frameshift mutation (rs28357092), leading to a distortion of the C-terminal end of the molecule, occurs in people without...

  • Indications for the Immunological Evaluation of Patients with Meningitis. Overturf, Gary D. // Clinical Infectious Diseases;1/15/2003, Vol. 36 Issue 2, p189 

    Although people with bacterial meningitis lack adequate protective antibody against the invading pathogen, most do not have an underlying immunodeficiency. Certain comorbid conditions increase the risk for development of bacterial sepsis and meningitis. In addition, certain congenital complement...

  • Mannose-binding Lectin Deficiency in Patients with a History of Recurrent Infections. Rashidi, Elahe; Fazlollahi, Mohammad Reza; Zahedifard, Sara; Talebzadeh, Azadeh; Kazemnejad, Anoshirvan; Saghafi, Shiva; Pourpak, Zahra // Iranian Journal of Allergy, Asthma & Immunology;Feb2016, Vol. 15 Issue 1, p69 

    Mannose-binding lectin (MBL) is a protein of innate immune system that is involved in opsonization and complement activation. MBL deficiency is associated with predisposition to infectious diseases; however subnormal levels are also seen in healthy subjects. The aim of this study was to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics