Use of vitamin supplements and risk of total cancer and cardiovascular disease among the Japanese general population: A population-based survey

Hara, Azusa; Sasazuki, Shizuka; Inoue, Manami; Shimazu, Taichi; Iwasaki, Motoki; Sawada, Norie; Yamaji, Taiki; Ishihara, Junko; Iso, Hiroyasu; Tsugane, Shoichiro
January 2011
BMC Public Health;2011, Vol. 11 Issue 1, p540
Academic Journal
Background: Despite the popular use of vitamin supplements and several prospective cohort studies investigating their effect on cancer incidence and cardiovascular disease (CVD), scientific data supporting their benefits remain controversial. Inconsistent results may be partly explained by the fact that use of supplements is an inconsistent behavior in individuals. We examined whether vitamin supplement use patterns affect cancer and CVD risk in a population-based cohort study in Japan. Methods: A total of 28,903 men and 33,726 women in the Japan Public Health Center-based Prospective Study cohort, who answered questions about vitamin supplement use in the first survey from 1990-1994 and the second survey from 1995-1998, were categorized into four groups (never use, past use, recent use, and consistent use) and followed to the end of 2006 for cancer and 2005 for CVD. Sex-specific hazard ratios (HRs) and 95% confidence intervals (95% CIs) were used to describe the relative risks of cancer and CVD associated with vitamin supplement use. Results: During follow-up, 4501 cancer and 1858 CVD cases were identified. Multivariate adjusted analysis revealed no association of any pattern of vitamin supplement use with the risk of cancer and CVD in men. In women, consistent use was associated with lower risk of CVD (HR 0.60, 95% CI 0.41-0.89), whereas past (HR 1.17, 95% CI 1.02-1.33) and recent use (HR 1.24, 95% CI 1.01-1.52) were associated with higher risk of cancer. Conclusions: To our knowledge, this is the first prospective cohort study to examine simultaneously the associations between vitamin supplement use patterns and risk of cancer and CVD. This prospective cohort study demonstrated that vitamin supplement use has little effect on the risk of cancer or CVD in men. In women, however, consistent vitamin supplement use might reduce the risk of CVD. Elevated risk of cancer associated with past and recent use of vitamin supplements in women may be partly explained by preexisting diseases or unhealthy background, but we could not totally control for this in our study.


Related Articles

  • Routine Vitamin Supplementation to Prevent Cancer and Cardiovascular Disease: Recommendations and Rationale. Berg, Alfred O. // American Family Physician;12/15/2003, Vol. 68 Issue 12, p2422 

    Summarizes the U.S. Preventive Services Task Force recommendations on routine vitamin supplementation to prevent cancer and cardiovascular disease. Clinical considerations; Discussion of the findings of the review.

  • Cholesterol, Cholesterol-Lowering Agents/Statins, and Urologic Disease: Part IV -- Is Vitamin E Phosphate or Another Unique Type Of this Vitamin the Last Chance for These Supplements? Moyad, Mark A.; Robinson, Larry E. // Urologic Nursing;Oct2006, Vol. 26 Issue 5, p415 

    The article offers information on a variety of vitamin E supplements and the clinical trials that have been made to determine the safety issues and their impact on cardiovascular disease (CVD) risk markers. The first vitamin E study was Linxian, a China trial which used dietary supplements to...

  • Can Vitamins Prevent Cancer and Heart Disease? Sadovsky, Richard // American Family Physician;2/1/2004, Vol. 69 Issue 3, p631 

    Discusses the study "Routine Vitamin Supplementation to Prevent Cancer and Cardiovascular Disease: Recommendations and Rationale," by A.O. Berg, published on the July 1, 2003 issue of the "Annals of Internal Medicine."

  • Multivitamins don't prevent. Investor's Business Daily // Investors Business Daily;12/18/2013, pA02 

    Multivitamins don't prevent chronic diseases, according to a researcher at Johns Hopkins Univ. School of Medicine. A study found that multivitamins had no effect on preventing cardiovascular disease or cancer, disappointing news for the 3rd of U.S. adults who take them to supplement their diets....

  • Heart Disease Supplements Being Threatened. Williams, Rose Marie // Townsend Letter for Doctors & Patients;Aug/Sep2004, Issue 253/254, p145 

    Reports on the recommendation of nutritional supplements for improving cardiovascular function among patients in the U.S. Action of vitamin C as antioxidant and co-factor for biochemical reactions; Protective role of vitamin E against free radicals and oxidative damage; Importance of B vitamins...

  • Clinical digest. Daily use of multivitamins fails to reduce men's risk of major cardiovascular events.  // Nursing Standard;12/12/2012, Vol. 27 Issue 15-17, p17 

    The article discusses research which was reported in the article "Multivitamins in the Prevention of Cardiovascular Disease in Men: The Physicians' Health Study II Randomized Controlled Trial" by H. Sesso et al. and found that the daily use of multivitamins fails to reduce men's risk of major...

  • Cancer Prevention for Men.  // Better Nutrition;Feb2005, Vol. 67 Issue 2, p16 

    This article presents information related to a study conducted to observe the influence of dietary supplements on reducing incidences of cancer. French scientists report that long-term supplementation with a broad spectrum of antioxidants may reduce the incidence of cancer in men, as well as...

  • Why Doctors Recommend Supplements.  // Better Nutrition;Jan2009, Vol. 71 Issue 1, p8 

    The article presents information on the findings of a survey of 1,200 health care professionals, according to which 79% of physicians recommend dietary supplements to their patients. The survey also found that 72% of physicians take supplements for their own health. Doctors' top personal choices...

  • CRN weighs in on vitamin supplements and heart disease, cancer.  // Primary Care Optometry News;Apr2014, Vol. 19 Issue 4, p20 

    The article reports on the final report of the U.S. Preventive Services Task Force which states that vitamin supplement use is insufficient as the primary prevention of cardiovascular disease and cancer.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics