TITLE

Polymorphisms of VEGFA gene and susceptibility to hemorrhage risk of brain arteriovenous malformations in a Chinese population

AUTHOR(S)
Gong, Zhi-ping; Qiao, Ni-dan; Gu, Yu-xiang; Song, Jian-ping; Li, Pei-liang; Qiu, Hui-jia; Fan, Wei-wei; Mao, Ying; Chen, Hong-yan; Zhao, Yao
PUB. DATE
August 2011
SOURCE
Acta Pharmacologica Sinica;Aug2011, Vol. 32 Issue 8, p1071
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim:To evaluate the influence of the vascular endothelial growth factor A (VEGFA) polymorphisms on risk of presentation with intracerebral hemorrhage (ICH).Methods:Nine selected VEGFA single-nucleotide polymorphisms (SNPs) were genotyped in 311 patients with brain arteriovenous malformations (BAVM) in a Chinese population. Associations between individual SNPs/haplotypes and the hemorrhage risk of BAVMs were evaluated using logistic regression analysis.Results:In the single-locus analysis, rs1547651 was associated with increased risk of ICH (adjusted OR=2.11, 95% CI=1.01-4.42 compared with the AA genotype). In particular, an increased risk for ICH was associated with this variant in female patients (adjusted OR=3.21, and 95% CI=0.99-10.36). Haplotype-based analyses revealed that haplotype 'GC' in block 1 and haplotype 'ACC' in block 2 were associated with a 30%-38% reduction in the risk of ICH in patients with BAVMs compared to the most common haplotype (Psim=0.033 and Psim=0.005, respectively). The protective effect of haplotype 'ACC' in block 2 was more evident in male patients and subjects with BAVMs of a size ≥3 cm (adjusted OR=0.57, 95% CI=0.34-0.97 and adjusted OR=0.57, 95% CI=0.31-0.86, respectively).Conclusion:The results suggest that VEGFA gene variants may contribute to ICH risk of BAVM.
ACCESSION #
63714051

 

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