TITLE

Induction of EGFR-Dependent and EGFR-Independent Signaling Pathways by Ultraviolet A Irradiation

AUTHOR(S)
Zhang, Yiguo; Dong, Ziming; Bode, Ann M.; Ma, Wei-Ya; Chen, Nanyue; Dong, Zigang
PUB. DATE
December 2001
SOURCE
DNA & Cell Biology;Dec2001, Vol. 20 Issue 12, p769
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Most of the signal pathways involved in ultraviolet (UV)-induced skin carcinogenesis are thought to originate at plasma membrane receptors. However, UVA-induced signal transduction to downstream ribosomal protein S6 kinases, p70[sup S6K] and p90[sup RSK], is not well understood. In this report, we show that UVA stimulation of the epidermal growth factor receptor (EGFR) may lead to activation of p70[sup S6K]/p90[sup RSK] through phosphatidyl isositol (PI)-3 kinase and extracellular receptor-activated kinases (ERKs). Evidence is provided that phosphorylation and activation of p70[sup S6K]/p90[sup RSK] induced by UVA were prevented in Egfr[sup -/-] cells and were also markedly inhibited by the EGFR-specific tyrosine kinase inhibitors AG1478 and PD153035. Furthermore, EGFR tyrosine kinase inhibitors and EGFR deficiency significantly suppressed activation of PI-3 kinase and ERKs in regulating activation of p90[sup RSK]/p70[sup S6K] but had no effect on activation of c-Jun NH[sub 2]-terminal kinases (JNKs) and p38 kinase in response to UVA. Thus, our results suggest that UVA-induced EGFR signaling may be required for activation of p90[sup RSK]/p70[sup S6K], PI-3 kinase, and ERKs but not JNKs or p38 kinase.
ACCESSION #
6366350

 

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