Detectable serum tobramycin concentrations in a patient with renal dysfunction receiving tobramycin by inhalation

Langley, Alissa; Cottingham, Lauren
August 2011
American Journal of Health-System Pharmacy;8/1/2011, Vol. 68 Issue 15, p1385
Academic Journal
In the article the authors discuss the detection of serum tobramycin concentrations in patients with renal dysfunction being treated with aerosolized tobramycin. They highlight the case of a 74-year-old African-American man with chronic kidney disease and Pseudomonas aeruginosa positive sputum cultures, and mention that he was treated with hemodialysis previously. It is suggested that serum tobramycin levels be monitored in patients with diminished renal function receiving inhaled tobramycin.


Related Articles

  • Tobramycin.  // Reactions Weekly;5/20/2006, Issue 1102, p14 

    Discusses research on two cases of renal toxicity due to inhaled tobramycin in lung transplant recipients. Reference to a study by R. Laporta and colleagues published in the May 2006 issue of the "Journal of Heart and Lung Transplantation"; Information on two male lung transplant recipients who...

  • Aztreonam lysine for inhalation solution: a guide to its use in cystic fibrosis.  // Drugs & Therapy Perspectives;Apr2011, Vol. 27 Issue 4, p1 

    Aztreonam lysine for inhalation solution (AZLI) is a new option for the treatment of Pseudomonas aeruginosa lung infection in patients with cystic fibrosis. When compared with placebo in clinical trials, AZLI improved respiratory symptoms, pulmonary function and sputum P. aeruginosa density,...

  • Indacaterol improves clinical benefits for COPD patients.  // British Journal of Hospital Medicine (17508460);Nov2011, Vol. 72 Issue 11, p609 

    The article reports the INTENSITY study, which compared Onbrez Breezhaler with Spiriva HandiHaler, and revealed that indacaterol is more beneficial than tiotropium for patients with chronic obstructive pulmonary disease (COPD).

  • Tobramycin.  // Reactions Weekly;12/10/2011, Issue 1381, p28 

    The article describes the clinical cases of seven patients who developed renal dysfunction following placement of tobramycin-impregnated cement spacers during revision knee or hip arthroplasty.

  • Goodpasture's Syndrome. Maddock Jr., R. K.; Stevens, L.; Reemtsma, K.; Bloomer, H. A. // Annals of Internal Medicine;Dec67, Vol. 67 Issue 6, p1258 

    Presents cases of patients with Goodpasture's syndrome that shed some light on the etiology, the pathogenesis, and the treatment of the condition. When nephrectomy must be considered for the condition; Suggestion regarding the pulmonary manifestation of Goodpasture syndrome.

  • Nebuliser hood compared to mask in wheezy infants: aerosol therapy without tears! Amirav I; Balanov I; Gorenberg M; Groshar D; Luder A S // Archives of Disease in Childhood;Aug2003, Vol. 88 Issue 8, p719 

    BACKGROUND: Small volume nebulisers (SVNs) with masks commonly provide aerosol therapy for infants with lung diseases. However, infants and toddlers are often disturbed by and thus reject masks. AIMS: To compare the lung deposition efficiency of the "usual" SVN aerosol mask and a prototype hood...

  • Nebulizers vs. MDIs with spacers for COPD or asthma. Miller, Karl // American Family Physician;6/1/1998, Vol. 57 Issue 11, p2836 

    Presents information on the nebulizer treatment which is recommended for the management of patients with acute exacerbations of chronic obstructive pulmonary diseases (COPD) or asthma. Requirements of the nebulizer treatment; Rating of symptom response after the treatment.

  • Prolastin aerosol therapy and sputum taurine in cystic fibrois. Cantin, AndrĂ© M.; Berthiaume, Yves; Cloutier, Diane; Martel, Marc // Clinical & Investigative Medicine;Aug2006, Vol. 29 Issue 4, p201 

    The article discusses the effects of Prolastin aerosol therapy on airway inflammation in cystic fibrosis. Prolastin is a therapeutic preparation of alpha-1 proteinase inhibitor, a neutrophil elastase inhibitor. It also presents a conclusion that aerosol therapy with Prolastin in patients with...

  • Wastage of drug from nebulisers: a review. Clay, Michelle M.; Clarke, Stewart W. // Journal of the Royal Society of Medicine;Jan1987, Vol. 80 Issue 1, p38 

    This article presents a review of data in literature about the wastage of respirator solution during nebulizer therapy. Although it is generally accepted that nebulizer therapy is effective in the treatment of chronic obstructive airways disease, grave concern has been expressed over its...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics