TITLE

FENOTIPURI DE REZISTENŢĂ PENTRU TULPINI DE ESCHERICHIA COLI ŞI KLEBSIELLA PNEUMONIAE PRODUCĂTOARE DE BETA-LACTAMAZE CU SPECTRU EXTINS (BLSE ), IZOLATE DIN INFECŢII URINARE

AUTHOR(S)
PETRAŞCU, MIRELA; FLONTA, MIRELA; ALMAŞ, ARIANA MIHAELA
PUB. DATE
September 2011
SOURCE
Clujul Medical;Sep2011, Vol. 84 Issue 3, p371
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives. In this study we analyzed the profile of resistance to suitable antibiotics for 155 isolates of Escherichia coli (71 isolates) and Klebsiella pneumoniae (84 isolates) producing extended-spectrum beta-lactamases (ESBLs). Material and methods. Strains of Escherichia coli and Klebsiella pneumoniae were isolated from urine samples in the Laboratory of Infectious Diseases Hospital Cluj-Napoca. The isolates were collected over a period of three years and four months (January 2007-April 2010). Isolates were identified on the chromagar media (Oxoid) and by Vitek 2 Compact system (BioMerieux). The sensitivity to antibiotic has been tested using the system Vitek2 Compact and antimicrobial disk susceptibility method. Results. Among the 71 ESBL isolates of Escherichia coli, 58 strains (81.7%) presented multiple resistance to antibiotics: aminoglycosides, quinolones, tetracycline, trimethoprim-sulfamethoxazole and nitrofurantoin. Among the 84 ESBL isolates of Klebsiella pneumoniae, 64 strains (76.2%) presented multiple resistance to antibiotics: aminoglycosides, quinolones, tetracycline, trimethoprim-sulfamethoxazole and nitrofurantoin. Conclusions. ESBL isolates of Escherichia coli and Klebsiella pneumoniae studied presented multiple resistance to antibiotics, especially to aminoglycosides, quinolones and trimethoprim-sulfamethoxazole. To stop the spread of bacterial strains resistant to antibiotics requires detailed knowledge of the mechanisms of bacterial resistance in parallel with the development and implementation of hospital policies for prescriptions of antibiotics, financial requirements imposed by antimicrobial treatment and the additional measures on control of microorganisms that can cause nosocomial infections.
ACCESSION #
63612443

 

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