High frequency of chlamydial co-infections in clinically healthy sheep flocks

Lenzko, Hannah; Moog, Udo; Henning, Klaus; Lederbach, Robert; Diller, Roland; Menge, Christian; Sachse, Konrad; Sprague5, Lisa D.
January 2011
BMC Veterinary Research;2011, Vol. 7 Issue 1, p29
Academic Journal
Background: The epidemiological situation of ovine chlamydial infections in continental Europe, especially Germany is poorly characterised. Using the German state of Thuringia as a model example, the chlamydial seroand antigen prevalence was estimated in thirty-two randomly selected sheep flocks with an average abortion rate lower than 1%. Seven vaccinated flocks were reviewed separately. Results: A wide range of samples from 32 flocks were examined. Assumption of a seroprevalence of 10% (CI 95%) at flock level, revealed that 94% of the tested flocks were serologically positive with ongoing infection (i.e. animals with seroconversion) in nearly half (47%) of the flocks. On the basis of an estimated 25% antigen prevalence (CI 95%), PCR and DNA microarray testing, together with sequencing revealed the presence of chlamydiae in 78% of the flocks. The species most frequently found was Chlamydophila (C.) abortus (50%) followed by C. pecorum (47%) and C. psittaci genotype A (25%). Mixed infections occurred in 25% of the tested flocks. Samples obtained from the vaccinated flocks revealed the presence of C. abortus field samples in 4/7 flocks. C. pecorum was isolated from 2/7 flocks and the presence of seroconversion was determined in 3/7 flocks. Conclusions: The results imply that chlamydial infections occur frequently in German sheep flocks, even in the absence of elevated abortion rates. The fact that C. pecorum and the potentially zoonotic C. psittaci were found alongside the classical abortifacient agent C. abortus, raise questions about the significance of this reservoir for animal and human health and underline the necessity for regular monitoring. Further studies are needed to identify the possible role of C. psittaci infections in sheep.


Related Articles

  • Appraisal of Microbial Evolution to Commensalism and Pathogenicity in Humans. Ghosh, Asit Ranjan // Clinical Medicine Insights: Gastroenterology;2013, Issue 6, p1 

    The human body is host to a number of microbes occurring in various forms of host-microbe associations, such as commensals, mutualists, pathogens and opportunistic symbionts. While this association with microbes in certain cases is beneficial to the host, in many other cases it seems to offer no...

  • MANAGING DISEASE IN WILD SHEEP IN BRITISH COLUMBIA. AYOTTE, JEREMY // BC Outdoors Hunting & Shooting;Fall2014, Vol. 70 Issue 2, p16 

    The article presents information on managing disease in wild sheep in British Columbia. North America's wild sheeps have little immunity to various diseases carried by domestic sheep and goats. The British Columbia Sheep Separation Program (BCSSP) wild sheep of British Columbia promotes healthy...

  • Indian research may further Australia's sheep success. Bromilow, Gavan // Australian Geographic;Jan-Mar2000, Issue 57, p20 

    Focuses on the Nimbkar Agricultural Research Institute in Phaltan, India, which studied the disease resistance of garole sheep. Role of the Australian Centre for International Agricultural Research in the study; Impact of the study on Australia's fine-wool industry.

  • Reasons behind anthelmintic resistance. Buss, Jessica // Farmers Weekly;6/3/2005, Vol. 142 Issue 22, p36 

    Reports on an investigation to be conducted by researchers at ADAS Pwllpeiran to identify the scale of resistance of sheep flocks to anthelmintic in Wales. Indications of the appearance of anthelmintic resistance for the animal industry.

  • Prediction Using C. trachomatis Cell-Mediated Immune Response.  // Fertility Weekly;8/14/2006, p3 

    The article presents information on a study undertaken by A. Tiitinen and colleagues in Finland regarding human infertility. The study aims at ascertaining whether the signs for C. trachomatis-specified humoral and cell-mediated immune behavior would accurately predict tubal factor infertility...

  • Chlamydial polymorphic membrane proteins: regulation, function and potential vaccine candidates. Vasilevsky, Sam; Stojanov, Milos; Greub, Gilbert; Baud, David // Virulence;2016, Vol. 7 Issue 1, p11 

    Pmps (Polymorphic Membrane Proteins) are a group of membrane bound surface exposed chlamydial proteins that have been characterized as autotransporter adhesins and are important in the initial phase of chlamydial infection. These proteins all contain conserved GGA (I, L, V) and FxxN tetrapeptide...

  • Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response. Wheelhouse, Nick; Coyle, Christopher; Barlow, Peter G.; Mitchell, Stephen; Greub, Gilbert; Baszler, Tim; Rae, Mick T.; Longbottom, David // PLoS ONE;Jul2014, Vol. 9 Issue 7, p1 

    Background: Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a member of the order Chlamydiales, and shares many similarities at the genome level and in growth studies with other...

  • Small ruminant lentiviruses in Jordan: evaluation of sheep and goat serological response using recombinant and peptide antigens. Tolari, Francesco; Al-Ramadneh, Wafa'a; Mazzei, Maurizio; Carrozza, Maria; Forzan, Mario; Bandecchi, Patrizia; Grego, Elena; Rosati, Sergio // Tropical Animal Health & Production;Aug2013, Vol. 45 Issue 6, p1335 

    Small ruminant lentiviruses infect sheep and goats worldwide, causing chronic progressive diseases and relevant economic losses. Disease eradication and prevention is mostly based on serological testing. The goal of this research was to investigate the presence of the small ruminant lentiviruses...

  • Liver enzymes in White Leghorns selected for the sheep red blood cell immune response. Blevins, S.; Siegel, P. B.; Blodgett, D. J.; Ehrich, M.; Lewis, R. M. // Poultry Science;Feb2012, Vol. 91 Issue 2, p322 

    Liver enzymes are essential to xenobiotic metabolism. Expression of these enzymes is dependent upon factors such as age and sex. The objective of this study was to determine basal liver enzyme levels in male and female White Leghorn chickens to provide reference values for future studies....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics