Thirty Years of HIV and AIDS: Future Challenges and Opportunities

Dieffenbach, Carl W.; Fauci, Anthony S.
June 2011
Annals of Internal Medicine;6/7/2011, Vol. 154 Issue 11, p766
Academic Journal
As the third decade since AIDS was first recognized comes to an end, extraordinary advances have occurred in the understanding, treatment, and prevention of HIV infection and AIDS. As a result of these successes, it is now time to focus on future challenges. Paramount among these is reaching the goal of truly controlling and ultimately ending the HIV and AIDS pandemic. To that end, AIDS researchers and public health personnel world- wide are aggressively pursuing 3 key areas of scientific research. Given the availability of highly effective therapeutic regimens for HIV infection, the first challenge is efficiently identifying a maximum number of HIV-infected persons through voluntary HIV testing and initiating antiretroviral therapy (ART). Second, scientists are trying to develop a cure for HIV infection, which would alleviate the need for lifelong ART. Finally, preventing new cases of HIV infection, which currently number approximately 2.6 million per year globally, is critical to any attempt to end this pandemic. This article addresses each of these challenges and provides directions for the future.


Related Articles

  • History and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African region. Wilkinson, Eduan; Engelbrecht, Susan; de Oliveira, Tulio // Scientific Reports;11/20/2015, p16897 

    HIV has spread at an alarming rate in South Africa, making it the country with the highest number of HIV infections. Several studies have investigated the histories of HIV-1 subtype C epidemics but none have done so in the context of social and political transformation in southern Africa. There...

  • Addressing the Achilles' Heel in the HIV Care Continuum for the Success of a Test-and-Treat Strategy to Achieve an AIDS-Free Generation. Nachega, Jean B.; Uthman, Olalekan A.; del Rio, Carlos; Mugavero, Michael J.; Rees, Helen; Mills, Edward J. // Clinical Infectious Diseases;Jul2014, Vol. 59 Issue suppl_1, pS21 

    Mathematical models and recent data from ecological, observational, and experimental studies show that antiretroviral therapy (ART) is effective for both treatment and prevention of HIV, validating the treatment as prevention (TasP) approach. Data from a variety of settings, including...

  • Leveraging HIV Treatment to End AIDS, Stop New HIV Infections, and Avoid the Cost of Inaction. Sidibé, Michel; Zuniga, José M.; Montaner, Julio // Clinical Infectious Diseases;Jul2014, Vol. 59 Issue suppl_1, pS3 

    We have the tools at our disposal to significantly bend AIDS-related morbidity and mortality curves and reduce human immunodeficiency virus (HIV) incidence. It is thus essential to redouble our efforts to reach the goal of placing 15 million people on life-saving and -enhancing antiretroviral...

  • LONG WAY TO GO IN HIV FIGHT.  // Australian Nursing Journal;Dec2011/Jan2012, Vol. 19 Issue 6, p40 

    The article reports on the presentation of the 2011 Burnet Oration, which was given by Nobel Laureate professor Françoise Barré- Sinoussi at BMW Edge in Melbourne, Australia in October of 2011 and in which Barré- Sinoussi stated that the global effort against HIV and AIDS must continue.

  • Antiretroviral Strategies for Treatment of HIV. Naga Anusha, P. // Journal of Antivirals & Antiretrovirals;2011, Vol. 3 Issue 4, p55 

    Since 1981 when first AIDS cases were identified in United States followed by Africa there has been growing understanding in the trajectory of HIV/AIDS across the world. The disease has caused unpredicted suffering, loss of life and disruption of family, social and economic abilities. Many...

  • Impact of Pill Sharing on Drug Resistance Due to a Wide-Scale Oral Prep Intervention in Generalized Epidemics. Dimitrov, Dobromir; Boily, Marie-Claude; Mâsse, Benoît R.; Brown, Elizabeth R. // Journal of AIDS & Clinical Research;Special2012, Vol. 3 Issue S, Special section p1 

    Background: The first antiretroviral drug (Truvada) to be used as a pre-exposure prophylaxis (PrEP) in preventing HIV transmission is about to be approved. Behavioral studies suggest that a portion of users may share anti-retroviral drugs with sex partners, family, or friends. Pill sharing will...

  • The Effects of Fetal and Childhood Exposure to Antiretroviral Agents. Mas, Catherine M.; Miller, Tracie L.; Cordero, Christina; Dauphin, Danielle; White, Marie Boursiquot; Vila, Christie K.; Somarriba, Gabriel; Wilkinson, James D.; Lipshultz, Steven E. // Journal of AIDS & Clinical Research;Special2012, Vol. 3 Issue S, Special section p1 

    Purpose: The compliant use of combination antiretroviral therapy has virtually eliminated perinatal HIV transmission. Although antiretroviral drug toxicities in adults have been well documented, the effects of fetal and early childhood exposure to antiretroviral drugs on children of HIV-positive...

  • The 2013 Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS in HIV-Infected Koreans.  // Infection & Chemotherapy;Dec2013, Vol. 45 Issue 4, p455 

    While a variety of clinical guidelines for the diagnosis and treatment of HIV/AIDS are used extensively around the world, the implementation of such guidelines is not assured in Korea due to constraints with respect to the diagnostic tests and antiretroviral drugs currently available in the...

  • Tales from Tanzania. Aspinwall, Mary // Homeopathy Today;Winter2014, Vol. 34 Issue 4, p24 

    The article focuses on homeopathy treatments provided by Homeopathy for Health in Africa (HHA), a non-profit homeopathic organization in Tanzania which is affected by HIV/AIDS. Topics discussed include statistics of HIV infection in Tanzania, physiological effects of HIV infection and mechanism...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics