Study on Occupational Allergy Risks (SOLAR II) in Germany: Design and methods

Heinrich, Sabine; Peters, Astrid; Kellberger, Jessica; Ellenberg, Diana; Genuneit, Jon; Nowak, Dennis; Vogelberg, Christian; von Mutius, Erika; Weinmayr, Gudrun; Radon, Katja
January 2011
BMC Public Health;2011, Vol. 11 Issue 1, p298
Academic Journal
Background: SOLAR II is the 2nd follow-up of a population-based cohort study that follows the participants of ISAAC Phase Two recruited in Munich and Dresden in 1995/6. A first follow-up study was conducted 2002 and 2003 (SOLAR I). The aims of SOLAR II were to investigate the course of atopic diseases over puberty taking environmental and occupational risk factors into account. This paper describes the methods of the 2nd follow-up carried out from 2007 to 2009 and the challenges we faced while studying a population-based cohort of young adults. Methods: Wherever possible, the same questionnaire instruments were used throughout the studies. They included questions on respiratory and allergic diseases, domestic and occupational exposure and work related stress. Furthermore, clinical examinations including skin prick tests, spirometry and bronchial challenge with methacholine, exhaled nitric oxide (FeNO) and blood samples were employed at baseline and 2nd follow-up. As information from three studies was available, multiple imputation could be used to handle missing data. Results: Of the 3053 SOLAR I study participants who had agreed to be contacted again, about 50% had moved in the meantime and had to be traced using phone directories and the German population registries. Overall, 2904 of these participants could be contacted on average five years after the first follow-up. From this group, 2051 subjects (71%) completed the questionnaire they received via mail. Of these, 57% participated at least in some parts of the clinical examinations. Challenges faced included the high mobility of this age group. Time constraints and limited interest in the study were substantial. Analysing the results, selection bias had to be considered as questionnaire responders (54%) and those participating in the clinical part of the study (63%) were more likely to have a high parental level of education compared to non-participants (42%). Similarly, a higher prevalence of parental atopy (e. g. allergic rhinitis) at baseline was found for participants in the questionnaire part (22%) and those participating in the clinical part of the study (27%) compared to non-participants (11%). Conclusions: In conclusion, a 12-year follow-up from childhood to adulthood is feasible resulting in a response of 32% of the baseline population. However, our experience shows that researchers need to allocate more time to the field work when studying young adults compared to other populations.


Related Articles

  • Sensitisation to cereal flour allergens is a major determinant of elevated exhaled nitric oxide in bakers. Baatjies, Roslynn; Jeebhay, Mohamed Fareed // Occupational & Environmental Medicine;May2013, Vol. 70 Issue 5, p310 

    Objective Various studies of the usefulness of fractional exhaled nitric oxide (FeNO) in occupational settings remain inconclusive. The objective was to investigate the determinants of increased FeNO in bakery workers. Methods A cross-sectional study of 424 supermarket bakery workers used a...

  • Increased nitric oxide in exhaled air: an early marker of asthma in non-smoking aluminium potroom workers? Lund, M.B.; Øksne, P.I.; Hamre, R.; Kongerud, J.; Oksne, P I // Occupational & Environmental Medicine;Apr2000, Vol. 57 Issue 4, p274 

    Objectives: To study exhaled nitric oxide (NO) as a marker of airway inflammation caused by potroom exposure, hypothesising that (a) workers exposed to potroom pollutants would have higher concentrations of NO in expired air than control subjects employed at the same plant but...

  • Within this issue. Bellanti, Joseph A.; Settiane, Russell A. // Allergy & Asthma Proceedings;Sep/Oct2013, Vol. 34 Issue 5, p389 

    The article discusses various papers published in this issue including one by Hsu et al. on the use of fractional exhaled nitric oxide (FeNO), one by Clark et al. on food allergy and one by Santillan et al. on asthma.

  • SORTING NEXIN 1 Functions in Plant Salt Stress Tolerance Through Changes of NO Accumulation by Regulating NO Synthase-Like Activity. Li, Ting-Ting; Liu, Wen-Cheng; Wang, Fang-Fang; Ma, Qi-Bin; Lu, Ying-Tang; Yuan, Ting-Ting // Frontiers in Plant Science;11/6/2018, pN.PAG 

    Nitric oxide (NO) production via NO synthase (NOS) plays a vital role in plant tolerance to salt stress. However, the factor(s) regulating NOS-like activity in plant salt stress tolerance remains elusive. Here, we show that Arabidopsis SORTING NEXIN 1 (SNX1), which can restore H2O2-induced NO...

  • Health worries over European chemical use.  // RoSPA Occupational Safety & Health Journal;May2009, Vol. 39 Issue 5, p9 

    The article focuses on a report published by the European Agency for Safety and Health at Work, which focused on 10 risks which could present new hazards to workers. The risks could contribute to various diseases, from allergies to infertility and cancer. 74,000 work-related fatalities across...

  • The dust settles. Romano-Woodward, Diane // Occupational Health;Oct2010, Vol. 62 Issue 10, p16 

    The article focuses on the 2010 British Occupational Health Research Foundation (BOHRF) Occupational Asthma (OA) Guidance. The guidelines were undertaken in 2010 by an occupational health physician, respiratory physicians and a scientific secretary. Key recommendations in the guidelines include...

  • Caution: Work can be hazardous to health. Forster, Jeff; Fedoruk, M. Joseph // Patient Care;2/15/1996, Vol. 30 Issue 3, p70 

    Discusses health hazards in the workplace. Work style and work environment assessment; Physician's role in ensuring a healthy working environment; Common noxious substances in the workplace; Reproductive hazards; Overuse injuries; Psycho-emotional hazards. INSETS: Teens and jobs: A potentially...

  • Work-linked illness up in U.K. Fernberg, Patricia M. // Occupational Hazards;Oct99, Vol. 61 Issue 10, p49 

    Cites a Great Britain study which revealed the rise in work-linked illnesses in the country.

  • Insight: Questions.  // Occupational Medicine;1999, Vol. 49 Issue 8, p574 

    No abstract available.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics