TITLE

Transforming Growth Factor-Beta and the Kidney: What We Know and What We Can Do?

AUTHOR(S)
Hai-Chun Yang; Yiqin Zuo; Fogo, Agnes B.
PUB. DATE
July 2010
SOURCE
Current Enzyme Inhibition;Jul2010, Vol. 6 Issue 2, p87
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Transforming growth factor-� (TGF-�) and its receptors are expressed in the kidney. The effects of TGF-� are mainly through activation of Smad pathways. In different pathophysiological situations such as development, immunomodulation, fibrosis and cell response, TGF-� interacts with other factors including angiotensin II, plasminogen activator inhibitor-1, connective tissue growth factor, integrins, and thymosin �4. Clinical studies have shown that specific polymorphisms of TGF-� genes and increased serum, urine and biopsied specimen levels are associated with human renal diseases. However, the effects of inhibition of TGF-� system are complex, depending on the injury type, disease stage and dosage of the inhibitor. Several animal studies have shown beneficial effects anti-TGF-� especially in chronic renal diseases, while data from clinical studies are still limited. In this review, current knowledge about the role of TGF-� system in the kidney and potential of strategies to modulate TGF-� for renoprotection are discussed.
ACCESSION #
62641908

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics