TITLE

TOXICOLOGICAL STUDY OF MEBUDIPINE AND DIBUDINE, TWO NEW CALCIUMCHANNEL BLOCKERS, IN SACCHAROMYCES CERVISES AND ISOLATED RAT HEPATOCYTES CELLS INVITRO

AUTHOR(S)
Mahmoudian, M.; Fallahati, M.; Faizi, M.; Bohlooli, S.; Sofian, N. D.
PUB. DATE
July 2011
SOURCE
International Journal of Pharmacy & Pharmaceutical Sciences;Jul2011, Vol. 3 Issue 3, p204
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Mebudipine and Dibudipine are two new calcium antagosists used in laboratory animals. Toxicological testing were evaluated in cultured mouse cells in-vitro and on growth yeast cells . It is shown that in these two system it is safe and no toxicological effect has been shown. Therefore, it is concluded that considering effect of mebudipne on yeast cells, heptocytes cells in-vitro, and reported effect on salmonella11, it can be said that is drug is safe and can be used in humans.
ACCESSION #
62639384

 

Related Articles

  • Anti-Convulsant Effect of Diltiazem on Lindane-Induced Toxicity in Mice. Khayatnouri, M. H. // Research Journal of Biological Sciences;Dec2011, Vol. 6 Issue 12, p666 

    Microbial resistance to antibiotics, especially among staphylococcal strains is a major thLindane a synthetic organochlorate poisons are used as insecticide. These toxins can be used insecticides in agriculture and medicine for destruction and/or eradication of ectoparasites of animals. Studies...

  • Comparative genetic activity of samples collected from two different urban waste incinerators. Vellosi, R.; Galli, A.; Rossi, F.; Morichetti, E.; Bronzetti, G. // Bulletin of Environmental Contamination & Toxicology;Sep1988, Vol. 41 Issue 3, p461 

    The article presents a study that analyzes the genotoxic activity of samples collected from urban incinerators in Florence, Italy and compared them with those from the Snampregetti incinerator of Schio (Vicenza). The study is conducted through the use of Salmonella typhimurium and Saccharomyces...

  • Antihyperglycemic and antinociceptive effects of a commercially produced beta-glucan from Saccharomyces cerevisiae in Swiss albino mice. Md. Tanvir Morshed; Shahnaz Rahman; Shiblur Rahman; Sharmin Jahan; Mohsina Mukti; Inin Taznin; Masta Hasenur Reza Chawdhury; Mohammed Rahmatullah // Advances in Natural & Applied Sciences;Jul-Sep2013, Vol. 7 Issue 3, p260 

    Beta-glucans are sugars that are found in the cell walls of bacteria, fungi, yeasts, algae, lichens, and plants, such as oats and barley. They are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds. Their major use is as a nutraceutical and it has been claimed that these...

  • Killed Saccharomyces cerevisiae Protects Against Lethal Challenge of Cryptococcus grubii. Majumder, Tanya; Liu, Min; Chen, Vicky; Martinez, Marife; Alvarado, Danielle; Clemons, Karl; Stevens, David // Mycopathologia;Oct2014, Vol. 178 Issue 3/4, p189 

    Heat-killed Saccharomyces cerevisiae (HKY) vaccination protects mice against aspergillosis, coccidioidomycosis, mucormycosis, or candidiasis. We studied HKY protection against murine cryptococcosis. Once weekly subcutaneous HKY doses (S, 6 × 10; 2S, 1.2 × 10; 3S, 2.4 × 10) began 28...

  • Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia. Hwang, Jung Seok; Choi, Hyuk Soo; Ham, Sun Ah; Yoo, Taesik; Lee, Won Jin; Paek, Kyung Shin; Seo, Han Geuk // Scientific Reports;11/6/2015, p15971 

    Inflammatory signal-mediated release of high-mobility group box 1 (HMGB1) is a damage-associated molecular pattern or alarmin. The inflammatory functions of HMGB1 have been extensively investigated; however, less is known about the mechanisms controlling HMGB1 release. We show that SIRT1, the...

  • Modulation of Intestinal Inflammation by Yeasts and Cell Wall Extracts: Strain Dependence and Unexpected Anti- Inflammatory Role of Glucan Fractions. Jawhara, Samir; Habib, Khalid; Maggiotto, François; Pignede, Georges; Vandekerckove, Pascal; Maes, Emmanuel; Dubuquoy, Laurent; Fontaine, Thierry; Guerardel, Yann; Poulain, Daniel // PLoS ONE;Jul2012, Vol. 7 Issue 7, p1 

    Yeasts and their glycan components can have a beneficial or adverse effect on intestinal inflammation. Previous research has shown that the presence of Saccharomyces cerevisiae var. boulardii (Sb) reduces intestinal inflammation and colonization by Candida albicans. The aim of this study was to...

  • Differential Effect of Troglitazone on the Human Bile Acid Transporters, MRP2 and BSEP, in the PXB Hepatic Chimeric Mouse. Foster, John R.; Jacobsen, Matt; Kenna, Gerry; Schulz-Utermoehl, Timothy; Morikawa, Yoshio; Salmu, Juuso; Wilson, Ian D. // Toxicologic Pathology;Dec2012, Vol. 40 Issue 8, p1106 

    The aims of this study were to assess the utility of the PXB mouse model of a chimeric human/mouse liver in studying human-specific effects of an important human hepatotoxic drug, the PPARγ agonist, troglitazone. When given orally by gavage for 7 days, at dose levels of 300 and 600 ppm,...

  • Relationship between DNA damage and micronucleus in mouse liver. Igarashi, Miyuki; Nagata, Mayumi; Itoh, Satoru; Yamoto, Takashi; Tsuda, Shuji // Journal of Toxicological Sciences;Dec2010, Vol. 35 Issue 6, p881 

    To determine the optimum timing of partial hepatectomy (PH) in a previously developed mouse liver micronucleus test (Igarashi and Shimada, 1997), the relation between DNA damage and micronucleus was examined using the in vivo alkaline comet assay and the micronucleus test on the liver of the...

  • Histological and Haematological Disturbance Caused by Arsenic Toxicity in Mice Model. Ferzand, Rubina; Gadahi, Javaid Ali; Saleha, Shamim; Ali, Qurban // Pakistan Journal of Biological Sciences;2008, Vol. 11 Issue 11, p1405 

    Histological and hematological disturbance caused by Arsenic containing water were studied in mice model. Animal were divided into four groups. Control group exposed to arsenic free distilled water and 3 treatment group exposed to the arsenic containing water with 30, 150 and 300 ppb. Blood...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics