TITLE

DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR DETERMINATION OF METOCLOPRAMIDE HYDROCHLORIDE IN BULK AND TABLET FORMULATION

AUTHOR(S)
Wamorkar, Vinay; Manjunath, S. Y.; Varma, M. Mohan
PUB. DATE
July 2011
SOURCE
International Journal of Pharmacy & Pharmaceutical Sciences;Jul2011, Vol. 3 Issue 3, p171
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The present research work discusses the development of UV-spectroscopic method for estimation of metoclopramide. Simple, specific, accurate and cost effective spectroscopic method has been developed for estimation of metoclopramide hydrochloride in bulk as well as formulation. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λmax) was found to be 272 nm. The validation was performed as per ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The method shows high sensitivity with linearity in the range of 2-20 μg/ml. all calibration curves shows a linear relationship between the absorbance and concentration with coefficient of correlation 0.998. The regression of curve was Y = 0.33x + 0.022. The precision of method was found to be good. The percentage recovery was found to be 100% ± SD. The optimized showed good reproducibility and recovery with standard deviation < 1 % and percent relative standard deviation less than 2 %, standard error in case of recovery studies are satisfactorily low and allow estimation metoclopramide in concentration range employed for this purpose in the assay of bulk drug and tablets. The sample solution was stable upto 36 hours. The proposed method will be suitable for analysis of metoclopramide in bulk as well as pharmaceutical formulations in quality control purpose. It is thus concluded that the proposed method is new, simple, cost-effective, safe, accurate, precise and environmental friendly.
ACCESSION #
62639375

 

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