TITLE

DEVELOPMENT AND IN VITRO EVALUATION OF MULTIPARTICULATE SYSTEM USING NOVEL COATING MATERIAL FOR CONTROLLED DRUG DELIVERY SYSTEM

AUTHOR(S)
Gandh, Bipin R.; Badgujar, Bhatu P.; Kasliwal, Ankit V.
PUB. DATE
July 2011
SOURCE
International Journal of Pharmacy & Pharmaceutical Sciences;Jul2011, Vol. 3 Issue 3, p96
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The objective of the present study was to develop and evaluate a multiparticulate system intended to utilize natural material for controlled drug delivery system. The system comprising of Cashew Gum coated pellets, designed for controlled drug delivery of Diltiazem hydrochloride. The sugar beads/pellets were loaded with drug (Diltiazem hydrochloride) using microcrystalline cellulose as a spheronizing aid and PVP K30 as a binder. Different coat weights of Cashew Gum were applied to the drug loaded pellets in Fluidized Bed Processor (FBP) to produce the controlled release drug delivery. Scanning electron microscopy revealed that the core pellets were discrete, spherical or oval with a slightly rough surface whereas the coated pellets were covered with a uniform and continuous Cashew Gum film. Optical microscopic image analysis portrayed that the values of aspect ratio and pellet circularity were close to 1.0 indicating the core pellets were almost spherical in shape. The friability with glass spheres was below 1.0%, signifying the core pellets produced were sufficiently hard. In vitro dissolution studies of the pellets performed which showed that the drug release from the coated pellets depend on the coat weights applied. Since, Diltiazem hydrochloride is a drug, which exhibits a high solubility, it would be possible to minimize drug release from coated pellets and effectively release the drug for controlled drug delivery system.
ACCESSION #
62639359

 

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