TITLE

Genome-wide linkage study of atopic dermatitis in West Highland White Terriers

AUTHOR(S)
Salzmann, Cary A.; Olivry, Thierry J. M.; Nielsen, Dahlia M.; Paps, Judith S.; Harris, Tonya L.; Olby, Natasha J.
PUB. DATE
January 2011
SOURCE
BMC Genetics;2011, Vol. 12 Issue 1, p37
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Canine atopic dermatitis (AD) is a common, heritable, chronic allergic skin condition prevalent in the West Highland White Terrier (WHWT). In canine AD, environmental allergens trigger an inflammatory response causing visible skin lesions and chronic pruritus that can lead to secondary bacterial and yeast infections. The disorder shares many of the clinical and histopathological characteristics of human AD and represents an animal model of this disorder that could be used to further elucidate genetic causes of human AD. Microsatellite markers genotyped in families of WHWTs affected with AD were used to perform a genome-wide linkage study in order to isolate chromosomal regions associated with the disorder. Results: Blood samples and health questionnaires were collected from 108 WHWTs spanning three families. A linkage simulation using these 108 dogs showed high power to detect a highly penetrant mutation. Ninety WHWTs were genotyped using markers from the Minimal Screening Set 2 (MSS-2). Two hundred and fifty six markers were informative and were used for linkage analysis. Using a LOD score of 2.7 as a significance threshold, no chromosomal regions were identified with significant linkage to AD. LOD scores greater than 1.0 were located in a 56 cM region of chromosome 7. Conclusions: The study was unable to detect any chromosomal regions significantly linked to canine AD. This could be a result of factors such as environmental modification of phenotype, incorrect assignment of phenotype, a mutation of low penetrance, or incomplete genome coverage. A genome-wide SNP association study in a larger cohort of WHWTs may prove more successful by providing higher density coverage and higher statistical power.
ACCESSION #
62608284

 

Related Articles

  • A common variant on chromosome 11q13 is associated with atopic dermatitis. Esparza-Gordillo, Jorge; Weidinger, Stephan; Fölster-Holst, Regina; Bauerfeind, Anja; Ruschendorf, Franz; Patone, Giannino; Rohde, Klaus; Marenholz, Ingo; Schulz, Florian; Kerscher, Tamara; Hubner, Norbert; Wahn, Ulrich; Schreiber, Stefan; Franke, Andre; Vogler, Rainer; Heath, Simon; Baurecht, Hansjörg; Novak, Natalija; Rodriguez, Elke; Illig, Thomas // Nature Genetics;May2009, Vol. 41 Issue 5, p596 

    We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional...

  • Phenotypes of atopic dermatitis.  // Advances in Psoriasis & Inflammatory Skin Diseases;2011, Vol. 2 Issue 4, p140 

    The article presents information about clinical phenotypes of atopic dermatitis. The most common atopic dermatitis phenotype classifications include extrinsic versus intrinsic atopic eczema, atopic dermatitis affecting different skin regions and several morphological variants, including nummular...

  • Atopic dermatitis: Breaking it down. Gagnon, Louise // Dermatology Times;Mar2006, Vol. 27 Issue 3, p46 

    The article discusses the differences of the extrinsic atopic dermatitis and intrinsic atopic dermatitis which has similar phenotype and histopathology but have different subsets of the disease process. It offers information about the differences of the two dermatitis, the treatment options of...

  • ORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations. Wei-Chiao Chang; Chih-Hung Lee; Tomomitsu Hirota; Li-Fang Wang; Satoru Doi; Miyatake, Akihiko; Enomoto, Tadao; Tomita, Kaori; Sakashita, Masafumi; Yamada, Takechiyo; Fujieda, Shigeharu; Ebe, Koji; Saeki, Hidehisa; Takeuchi, Satoshi; Masutaka Furue; Wei-Chiao Chen; Yi-Ching Chiu; Wei Pin Chang; Chien-Hui Hong; Edward Hsi // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD...

  • Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children. He, J-Q; Chan-Yeung, M; Becker, A B; Dimich-Ward, H; Ferguson, A C; Manfreda, J; Watson, W T A; Sandford, A J // Genes & Immunity;Aug2003, Vol. 4 Issue 5, p385 

    We studied a cohort containing 368 children at high risk of developing atopy and atopic disorders and 540 parents of those children to investigate whether the IL13 Arg130Gln and C-1112 T polymorphisms were associated with these outcomes. We also investigated whether haplotypes consisting of any...

  • High Expression Levels of Keratinocyte Antimicrobial Proteins in Psoriasis Compared with Atopic Dermatitis. Jongh, Gys J.; Zeeuwen, Patrick L. J. M.; Kucharekova, Martina; Pfundt, Rolph; Valk, Pieter G.; Blokx, Willeke; Dogan, Aynur; Hiemstra, Pieter S.; Kerkhof, Peter C.; Schalkwijk, Joost // Journal of Investigative Dermatology;Dec2005, Vol. 125 Issue 6, p1163 

    Recently, it was shown that lesional skin of atopic dermatitis patients expresses low levels of some antimicrobial peptides, compared with psoriasis patients. Here we performed microarray analysis on mRNA from purified lesional epidermal cells of patients with chronic plaque psoriasis and...

  • ORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations. Wei-Chiao Chang; Chih-Hung Lee; Tomomitsu Hirota; Li-Fang Wang; Satoru Doi; Miyatake, Akihiko; Enomoto, Tadao; Tomita, Kaori; Sakashita, Masafumi; Yamada, Takechiyo; Fujieda, Shigeharu; Ebe, Koji; Saeki, Hidehisa; Takeuchi, Satoshi; Masutaka Furue; Wei-Chiao Chen; Yi-Ching Chiu; Wei Pin Chang; Chien-Hui Hong; Edward Hsi // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD...

  • Allergic and Nonallergic Asthma in Children: Are They Distinct Phenotypes? Mahdaviani, Seyed Alireza; Mohajerani, Seyed Amir; Fakhri, Mohammad; Ebrahimi, Mazaher; Bashardoost, Bahram; Razavi, Seyed Jafar; Toolabi, Masoumeh; Tajik, Ali; Khalilzadeh, Soheila; Masjedi, Mohamad Reza // Iranian Journal of Allergy, Asthma & Immunology;Oct2014, Vol. 13 Issue 5, p370 

    The aim of current study is to describe clinical similarities and differences between atopic and non-atopic asthma in children. In a cross-sectional study, 95 asthmatic children (75 allergics and 20 nonallergics) were included in the study. Demographic, clinical, and familial history were...

  • Atopic dermatitis gene discovered.  // GP: General Practitioner;4/17/2009, p12 

    The article reports on a study of human genomes by German researchers. They analysed the genomes of 3,011 people and found a risk variant for atopic dermatitis on chromosome 11 of about 13% of European people. They identified a gene variant associated with a 47% increased risk of atopic...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics