TITLE

The effect of montelukast sodium on serum arginase levels in patients with seasonal allergic rhinitis

AUTHOR(S)
Yasar, Husamettin; Kiran, Bayram; Cagatay, Tulin; Ozkul, Haluk; Icten, Sacit
PUB. DATE
July 2011
SOURCE
American Journal of Rhinology & Allergy;Jul/Aug2011, Vol. 25 Issue 4, p153
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Nitric oxide (NO) imbalance appears to be important in the pathogenesis of allergic rhinitis. NO is synthesized from l-arginine by NO synthase (NOS). Competing with NOS for l-arginine is arginase, which catalyzes the hydrolysis of arginine to urea and ornithine. Therefore, increased serum arginase activity could potentially limit NO production catalyzed by inducible NOS, thus contributing to allergic rhinitis. This study was designed to investigate the effect of the cysteinyl leukotriene type 1 receptor antagonist, montelukast sodium on serum arginase levels in patients with seasonal allergic rhinitis. Methods: Twenty-five patients with seasonal allergic rhinitis (SAR; treatment group) and 16 nonasthmatic patients without allergic rhinitis (control group) were included in the study. Serum arginase levels and the mean total nasal symptoms scores were measured before and after oral montelukast sodium (10 mg) was administered daily for 4 weeks to the treatment group. Results: Serum arginase levels and the mean total nasal symptoms scores were significantly lower in the treatment group after montelukast sodium administration compared with the baseline levels (p = 0.001). Serum arginase levels were significantly lower in the treatment group compared with the control group (p = 0.01). There was no statistically significant difference between the serum arginase levels of the treatment group before treatment and the control group (p = 0.05). There was a weak correlation between the mean total nasal symptoms scores and serum arginase levels in the treatment group before montelukast sodium administration (rs = 0.40; p = 0.05). Conclusion: Montelukast sodium may reduce serum arginase levels and total nasal symptoms scores of patients with SAR. Additional studies that compare the effectiveness of nasal corticosteroid and montelukast sodium on serum arginase levels should be conducted.
ACCESSION #
62541144

 

Related Articles

  • EXPRESSION OF NITRIC OXIDE SYNTHASES IN NASAL MUCOSA FROM A MOUSE MODEL OF ALLERGIC RHINITIS. Seung Jun Oh, Luiz Ubirajara; Yang-Gi Min, Luiz Ubirajara; Seung-Ju Lee, Luiz Ubirajara; Jeong-Whun Kim, Luiz Ubirajara; Jarin, Peter R. // Annals of Otology, Rhinology & Laryngology;Oct2003, Vol. 112 Issue 10, p899 

    Nitric oxide (NO), which is produced by nitric oxide synthase (NOS), has been recently identified as a multifunctional mediator. As for nasal tissue, however, the distribution and expression patterns of 3 isoforms of NOS, including neuronal NOS (nNOS, type I NOS), inducible NOS (iNOS, type II...

  • Allergic rhinitis in asthmatic patients. Snelson, Catherine; Moudgil, Harmesh // Update;Apr2007, Vol. 74 Issue 4, p55 

    The article discusses the effects of allergic rhinitis on asthma patients. It refers to the investigation, diagnosis and management of the same. It's informed that optimal treatment of rhinitis may improve co-existing asthma, and some drugs, such as leukotriene receptor antagonists and...

  • Is there a role for leukotriene receptor antagonists in treating allergic rhinitis? Kaliner, Michael // Patient Care for the Nurse Practitioner;Oct2007, Vol. 10 Issue 10, p15 

    The article focuses on the role of leukotriene receptor antagonists (LTRAs) in treating allergic rhinitis (AR). While current guidelines acknowledge that LTRAs may have value in AR management, they do not provide specific recommendations because of a lack of available information regarding...

  • Increased expression of inducible nitric oxide synthase in nasal mucosae of guinea pigs with induced allergic rhinitis. Chiba, Yoshihiko; Matsuo, Kensuke; Sakai, Hiroyasu; Abe, Kazuho; Misawa, Miwa // American Journal of Rhinology;May/Jun2006, Vol. 20 Issue 3, p336 

    Background: Nitric oxide (NO) is produced by the action of NO synthase (NOS) isoforms and is considered an important mediator of inflammatory response including airways. In this study, the changes in the expression levels of NOS isoforms in nasal mucosae were determined in a guinea pig model of...

  • Localisation of heme oxygenase isoforms in allergic human nasal mucosa. Lo, Stephen; di Palma, Silvana; Pitkin, Lisa; McCombe, Andrew W. // European Archives of Oto-Rhino-Laryngology;Aug2005, Vol. 262 Issue 7, p595 

    Carbon monoxide (CO) is an endogenously produced gas mediator produced by heme oxygenase (HO). Like nitric oxide (NO), CO is produced in the nasal mucosa. Given that induced NO synthase (iNOS) expression in nasal mucosa has been found to be up-regulated in allergic rhinitis, the current study...

  • Dual Function of Nitric Oxide in Carcinogenesis, Reappraisal. Engin, Ayse Basak // Current Drug Metabolism;Nov2011, Vol. 12 Issue 9, p891 

    Nitric oxide, a unique signalling molecule, is synthesized from L-arginine by a family of isoenzymes called nitric oxide synthase. Function of nitric oxide largely depends on the concentrations of surrounding free radicals and redox state. The local concentration of the nitric oxide defines its...

  • ENZYME HISTOCHEMICAL EXPRESSION OF NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE-DIAPHORASE (NADPH-D) IN PARANAL SINUS, EXTERNAL AND INTERNAL ANAL SPHINCTERS IN DOGS. STEFANOV, I. S. // Bulgarian Journal of Veterinary Medicine;Jun2011, Vol. 14 Issue 2, p80 

    No abstract available.

  • RBC-NOS-Dependent S-Nitrosylation of Cytoskeletal Proteins Improves RBC Deformability. Grau, Marijke; Pauly, Sebastian; Ali, Jamal; Walpurgis, Katja; Thevis, Mario; Bloch, Wilhelm; Suhr, Frank // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Background: Red blood cells (RBC) possess a nitric oxide synthase (RBC-NOS) whose activation depends on the PI3-kinase/Akt kinase pathway. RBC-NOS-produced NO exhibits important biological functions like maintaining RBC deformability. Until now, the cellular target structure for NO, to exert...

  • Multitracer Stable Isotope Quantification of Arginase and Nitric Oxide Synthase Activity in a Mouse Model of Pseudomonas Lung Infection. Grasemann, Hartmut; Jaecklin, Thomas; Mehl, Anne; Huang, Hailu; Rafii, Mahroukh; Pencharz, Paul // Mediators of Inflammation;2014, Vol. 2014, p1 

    Cystic fibrosis airways are deficient for L-arginine, a substrate for nitric oxide synthases (NOSs) and arginases. The rationale for this study was to quantify NOS and arginase activity in themouse lung. Anesthetized unventilated mice received a primed constant stable isotope intravenous...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics