Association between severity of asthma and degree of chronic rhinosinusitis

Lin, David C.; Chandra, Rakesh K.; Tan, Bruce K.; Zirkle, Whitney; Conley, David B.; Grammer, Leslie C.; Kern, Robert C.; Schleimer, Robert P.; Peters, Anju T.
July 2011
American Journal of Rhinology & Allergy;Jul/Aug2011, Vol. 25 Issue 4, p205
Academic Journal
Background: There is a clinical association between asthma and chronic rhinosinusitis (CRS). This study was designed to determine whether severity of coexistent asthma affects the clinical presentation of CRS. Methods: Cross-sectional analysis was performed of prospectively collected data in 187 patients with CRS who were evaluated in a large, tertiary academic nasal and sinus center. Patients were stratified into three groups based on asthma status using National Institutes of Health criteria: (1) nonasthmatic, (2) intermittent/mild asthma, (3) or moderate/severe asthma. Results: Mean Lund-Mackay scores were 9.7, 11.6, and 15.6, respectively. ANOVA testing with post-hoc Tukey analysis revealed that Lund-MacKay scores were significantly greater in group 3 than either group 1 (p < 0.05) or group 2 (p < 0.01). The prevalence of allergic sensitization was 72.4, 82.8, and 100% in groups 1, 2, and 3, respectively (p = 0.03). The prevalence of nasal polyposis was 31.4% in group 1, 48.3% in group 2, and 94.4% in group 3 (p < 0.0001). No differences were observed regarding demographic factors or the incidence of the triad of aspirin sensitivity, asthma, and nasal polyposis among those with different severities of asthma. Conclusion: Increasing severity of asthma is associated with advancing radiological severity of CRS and a greater prevalence of allergic sensitization and nasal polyposis. This large adult series shows that asthma severity may have a significant correlation with the presentation of CRS. This study adds to the growing support for the unified airway theory.


Related Articles

  • Asthma patients often have more than co-existing allergies.  // Modern Medicine;May97, Vol. 65 Issue 5, p18 

    Reports on findings in the Asthma Outcomes Registry which shows that asthma patients have nasal polyps and sinusitis. Prevalence of nasal polyps in asthma patients with sinusitis compared with those without sinusitis; Percentage of patients with multiple upper respiratory conditions.

  • Correlation of exhaled nitric oxide, nasal nitric oxide and atopic status: A cross-sectional study in bronchial asthma and allergic rhinitis. Gupta, Nitesh; Goel, Nitin; Kumar, Raj // Lung India;Oct-Dec2014, Vol. 31 Issue 4, p342 

    Exhaled nitric oxide (FENO) and nasal nitric oxide (n NO) measurement is an area of ongoing research in the study of airway inflammation. The atopic status is known to influence the levels of FENO and n NO. This study was undertaken to study the relationship between nitric oxide measurements in...

  • The Efficacy of Clarithromycin in Patients with Severe Nasal Polyposis. Dabirmoghaddam, Payman; Jalal Mehdizadeh Seraj; Bastaninejad, Shahin; Meighani, Ali; Mokhtari, Zahra // Acta Medica Iranica;2013, Vol. 51 Issue 6, p359 

    Although several treatments have been suggested for nasal polyposis, from medical to surgical, there is no standard guideline for the management of this disease. During recent years increasing attention has been directed toward the effects of macrolide antibiotics on chronic sinusitis and nasal...

  • Perimenstrual Asthma: A High-Risk Phenotype. Kuritzky, Louis // Infectious Disease Alert;Jul2013 Clinical Breifs in Primary Care, p2 

    The article discusses research on the characteristics of perimenstrual asthma and its relation to asthma severity and control, referencing a study by C. K. Rao and colleagues published in an issue of "Chest."

  • Aspirin-sensitive asthma and upper airway diseases. Chang, Jinny E.; Chin, William; Simon, Ronald // American Journal of Rhinology & Allergy;Jan/Feb2012, Vol. 26 Issue 1, p27 

    Background: Aspirin exacerbated respiratory disease (AERD) consists of nasal polyposis, rhinosinusitis, asthma, and aspirin (ASA) sensitivity. Objective: This article details how to diagnose and treat AERD and describes the procedures associated with ASA challenge and desensitization, benefits...

  • A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps. Håkansson, Kåre; Thomsen, Simon Francis; Konge, Lars; Mortensen, Jann; Backer, Vibeke; von Buchwald, Christian // American Journal of Rhinology & Allergy;Sep/Oct2014, Vol. 28 Issue 5, p383 

    Background: Chronic rhinosinusitis (CRS) is a common health problem that is subclassified as CRS with nasal polyps (CRSwNPs) or CRS without NPs (CRSsNP). In accordance with the united airways concept, CRSwNPs frequently coexists with asthma but to date, this association remains unexplained and...

  • Objective Assessment of Lower Airway Involvement in Chronic Rhinosinusitis. Ragab, Ahmed; Clement, Peter; Vincken, Walter // American Journal of Rhinology;Jan/Feb2004, Vol. 18 Issue 1, p15 

    Background: When associated with lower airway involvement, the morbidity and the cost of chronic rhinosinusitis CRS) can increase. The aim of this prospective study was to assess the clinical and radiological characteristics of the upper airways in CRS patients scheduled for functional...

  • Relationships between severity of chronic rhinosinusitis and nasal polyposis, asthma, and atopy. Pearlman, Aaron N.; Chandra, Rakesh K.; Chang, Dennis; Conley, David B.; Tripathi-Peters, Anju; Grammer, Leslie C.; Schleimer, Robert T.; Kern, Robert C. // American Journal of Rhinology & Allergy;Mar2009, Vol. 23 Issue 2, p145 

    Background: The effect of comorbid conditions such as asthma and atopy on the severity of chronic rhinosinusitis (CRS) and the presence of nasal polyps (NPs) remains an area of investigation. We sought to elucidate the relationship among these entities. Methods: The study population included 106...

  • Vitamin D levels and status amongst asthmatic and non-asthmatic adolescents in Cyprus: a comparative cross-sectional study. Ourania Kolokotroni; Papadopoulou, Anna; Middleton, Nicos; Kouta, Christiana; Raftopoulos, Vasilios; Nicolaidou, Polyxeni; Yiallouros, Panayiotis K. // BMC Public Health;2015, Vol. 15 Issue 1, p1 

    Background: Emerging evidence suggests that vitamin D might be implicated in asthma pathophysiology. This study aims to compare Vitamin D mean serum levels and status between asthmatic and non-asthmatic adolescents and investigate the association of vitamin D with asthma severity. Methods: In a...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics