TITLE

Olopatadine 0.6% nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis

AUTHOR(S)
Smith, Peter K.; Collins, Joel
PUB. DATE
July 2011
SOURCE
American Journal of Rhinology & Allergy;Jul/Aug2011, Vol. 25 Issue 4, p149
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Vasomotor rhinitis (VMR) is a hypersensitivity syndrome with heightened reactivity to environmental triggers. Methods: Twenty-two patients with severe VMR were treated nasally with either normal saline or 0.6% olopatadine and challenged nasally with a hyperosmolar mannitol solution. Results: Treatment with 0.6% olopatadine resulted in an improvement in instantaneous nasal symptom scores at 5 and 30 minutes (p < 0.01) compared with baseline and at 30 minutes after hyperosmolar challenge compared with saline-pretreated individuals (p < 0.01). There was also an improvement in nasal peak inspiratory flow rate at 30 minutes after hyperosmolar challenge compared with saline-pretreated individuals (p < 0.01). Conclusion: In this patient population 0.6% olopatadine appears to be efficacious in symptom reduction in VMR and protects from hyperosmolar challenge.
ACCESSION #
62541131

 

Related Articles

  • Azelastine desensitization of transient receptor potential vanilloid 1: A potential mechanism explaining its therapeutic effect in nonallergic rhinitis. Singh, Umesh; Bernstein, Jonathan A.; Haar, Lauren; Luther, Kristin; Jones, Walter K. // American Journal of Rhinology & Allergy;May/Jun2014, Vol. 28 Issue 3, p215 

    Background: Capsaicin, a prototypic transient receptor potential vanilloid 1 (TRPV1) agonist, has been shown to be more clinically effective in the treatment of nonallergic rhinitis (NAR) compared with other rhinitis subtypes. Azelastine has also been found to be clinically effective in the...

  • An Overview of the Actions of Capsaicin and Its Receptor, TRPV1, and Their Relations to Small Primary Sensory Neurons. Hiura, Akio; Nakagawa, Hiroshi // Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry;Feb2011, Vol. 10 Issue 1, p2 

    No abstract available.

  • Evaluation of Treatment Satisfaction in Children with Allergic Disease Treated with an Antihistamine: An International, Non-Interventional, Retrospective Study. Ferrer, Marta; Morais-Almeida, Mário; Guizova, Margarita; Khanferyan, Roman // Clinical Drug Investigation;2010, Vol. 30 Issue 1, p15 

    Background and Objectives: Histamine H1-receptor antagonists (antihistamines) have been shown to be efficacious and safe in children and are recommended as first-line treatment for the symptoms of allergic rhinitis and urticaria. No published study to date has directly compared satisfaction with...

  • SPRING FEVER. Donaldson, Angela // Good Medicine (Australian Consolidated Press);Oct2002, p34 

    Presents advice on the treatment and prevention of hay fever during spring. Symptoms of hay fever; Treatment options; Benefits of consulting an allergy specialist.

  • Stop the sneezing and improve the breathing Managing allergic rhinitis. Davis, Sumari // South African Pharmacist's Assistant;Spring2016, Vol. 16 Issue 3, p6 

    The article discusses the management of allergic rhinitis or inflammation of the mucous membranes of the nose caused by an allergic reaction to inhaled allergens, causes, symptoms and management like avoiding allergens and triggers, and treatment and medication including normal saline nasal sprays.

  • Sensitivity Testing in Irritable Bowel Syndrome With Rectal Capsaicin Stimulations: Role of TRPV1 Upregulation and Sensitization in Visceral Hypersensitivity? van Wanrooij, Sander J M; Wouters, Mira M; Van Oudenhove, Lukas; Vanbrabant, Winde; Mondelaers, Stéphanie; Kollmann, Patrick; Kreutz, Florian; Schemann, Michael; Boeckxstaens, Guy E // American Journal of Gastroenterology;Jan2014, Vol. 109 Issue 1, p99 

    OBJECTIVES:Abnormal pain perception or visceral hypersensitivity (VH) is considered to be an important mechanism underlying symptoms in a subgroup of irritable bowel syndrome (IBS) patients. Increased TRPV1 (transient receptor potential cation channel subfamily V member 1) expression in rectal...

  • Hayfever remedies that really work.  // Health & Fitness Magazine;Jun2013, p44 

    The article provides remedies for hayfever. Allergy UK Chief Executive Officer (CEO) Lindsey McManus emphasizes the importance of planning ahead to manage the condition and start treatment. Determining what type of pollen allergy a person has allows one to predict when and what symptoms he is...

  • antihistamine drugs. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p57 

    An encyclopedia entry for "antihistamine drugs" is presented. They refer to a group of drugs that block the effects of the chemical histamine, which is released during allergic reactions. These drugs are used for the treatment of rashes such as uticaria and for relieving sneezing and a runny...

  • Desloratadine.  // AHFS Consumer Medication Information;Apr2018, p1 

    Desloratadine is used to relieve hay fever and allergy symptoms, including sneezing; runny nose; and red, itchy, tearing eyes. It is also used to treat hives. Desloratadine is in a class of medications called antihistamines. It works by blocking histamine, a substance in the body that causes...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics