Almac data improves diagnosis of cancer

July 2011
Worldwide Biotech;Jul2011, Vol. 23 Issue 7, p1
Trade Publication
The article shows the 2 primary research projects of Almac that enhance cancer screening. The first study focuses on ovarian cancer screening using the profiling process of a big clinical dataset of 363 sampled patients, where 6 molecular subgroups and 3 main biological subgroups of the cancer are identified from the patients. The other study assesses breast cancer screening, where the DNA damage response deficient molecular subgroup that has the potential to enhance chemotherapy or assess gene damage.


Related Articles

  • Genetic testing delivers ammo against cancer.  // South Asian Post;9/1/2011, p10 

    The article reports on the significance of Hereditary Breast and Ovarian Cancer syndrome (HBOC) test to identify one's risk for breast and ovarian cancer.

  • Cancer found earlier in next generation.  // Journal of Business (10756124);9/22/2011, Vol. 26 Issue 20, pB13 

    The article reports on a study by the University of Texas which found that women with harmful gene mutations are diagnosed with breast cancer eight years earlier than the relatives of the previous generation having ovarian cancer.

  • A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. Jie Shen; Christine B. Ambrosone; Richard A. DiCioccio; Kunle Odunsi; Shashikant B. Lele; Hua Zhao // Carcinogenesis;Oct2008, Vol. 29 Issue 10, p1963 

    A G to C polymorphism (rs2910164) is located within the sequence of miR-146a precursor, which leads to a change from a G:U pair to a C:U mismatch in its stem region. The predicted miR-146a target genes include BRCA1 and BRCA2, which are key breast and ovarian cancer genes. To examine whether...

  • Folate Receptor-Beta Has Limited Value for Fluorescent Imaging in Ovarian, Breast and Colorectal Cancer. de Boer, Esther; Crane, Lucia M. A.; van Oosten, Marleen; van der Vegt, Bert; van der Sluis, Tineke; Kooijman, Paulien; Low, Philip S.; van der Zee, Ate G. J.; Arts, Henriette J. G.; van Dam, Gooitzen M.; Bart, Joost // PLoS ONE;8/6/2015, Vol. 10 Issue 8, p1 

    Aims: Tumor-specific targeted imaging is rapidly evolving in cancer diagnosis. The folate receptor alpha (FR-α) has already been identified as a suitable target for cancer therapy and imaging. FR-α is present on ~40% of human cancers. FR-β is known to be expressed on several...

  • Ethnic, Racial and Cultural Identity and Perceived Benefits and Barriers Related to Genetic Testing for Breast Cancer among At-Risk Women of African Descent in New York City. Sussner, K.M.; Edwards, T.A.; Thompson, H.S.; Jandorf, L.; Kwate, N.O.; Forman, A.; Brown, K.; Kapil-Pair, N.; Bovbjerg, D.H.; Schwartz, M.D.; Valdimarsdottir, H.B. // Public Health Genomics;2011, Vol. 14 Issue 6, p356 

    Background: Due to disparities in the use of genetic services, there has been growing interest in examining beliefs and attitudes related to genetic testing for breast and/or ovarian cancer risk among women of African descent. However, to date, few studies have addressed critical cultural...

  • Jolie inspired women for breast cancer tests.  // Filipino Post;8/13/2015, p9 

    No abstract available.

  • The Canadian National Breast Screening Study: a perspective on criticisms. Baines, Cornelia J.; Baines, C J // Annals of Internal Medicine;2/15/94, Vol. 120 Issue 4, p326 

    Recently published 7-year results from the Canadian National Breast Screening Study (NBSS) generated much controversy and criticism. In women aged 40 to 49 years at entry, no reduction in breast cancer mortality was observed when screened women were compared with virtually unscreened women. In...

  • Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer. Burford, B; Gentry-Maharaj, A; Graham, R; Allen, D; Pedersen, J W; Nudelman, A S; Blixt, O; Fourkala, E O; Bueti, D; Dawnay, A; Ford, J; Desai, R; David, L; Trinder, P; Acres, B; Schwientek, T; Gammerman, A; Reis, C A; Silva, L; Osório, H // British Journal of Cancer;5/21/2013, Vol. 108 Issue 10, p2045 

    Background:Autoantibodies have been detected in sera before diagnosis of cancer leading to interest in their potential as screening/early detection biomarkers. As we have found autoantibodies to MUC1 glycopeptides to be elevated in early-stage breast cancer patients, in this study we analysed...

  • COMMUNICATING ABOUT CANCER RISK IN HIGH-RISK FAMILIES: A COMPARISON BETWEEN BREAST AND OVARIAN CANCER SURVIVORS AND THEIR FEMALE RELATIVES. Mellon, Suzanne; Berry-Bobovski, Lisa; Gold, Robin; Janisse, James; Tainsky, Michael // Oncology Nursing Forum;Jan2007, Vol. 34 Issue 1, p227 

    Although families live with a history of cancer that may signify a genetic risk such as BRCA1/2, few studies have examined communication within families about inherited breast/ovarian cancer risk. Understanding family communication patterns is critical to assist survivors and their family...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics