TITLE

Synthesis and In Vitro Cytotoxic Activity of 2-Amino-7-(dimethylamino)-4- [(trifluoromethyl)phenyl]-4H-chromenes

AUTHOR(S)
Mahdavi, M.; Asadipour, A.; Rajabalian, S.; Vosooghi, M.; Firoozpour, L.; Nakhjiri, M.; Shafiee, A.; Foroumadi, A.
PUB. DATE
April 2011
SOURCE
E-Journal of Chemistry;2011, Vol. 8 Issue 2, p598
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Three 2-amino-4-(trifluoromethylphenyl)-3-cyano-7-(dimethylamino)-4H-chromene derivatives were synthesized and their cytotoxic activities were determined against six human tumor cell lines using MTT assay. Condensation of 3-(dimethylamino)phenol, trifluoromethybenzaldehydes and malonitrile in ethanol containing piperidine afforded corresponding chromenes (4a-c). The structure of the synthesized compound was confirmed by 1H NMR, IR and Mass spectral data. Among compounds tested, 3-trifluoromethyl analogue (3b) was the most active against all human tumor cell lines (IC50=12-45 nM).
ACCESSION #
62086009

 

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