TITLE

Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3' chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole

AUTHOR(S)
Gupta, Shiv K.; Sharma, P. K.; Bansal, M.; Kumar, B.
PUB. DATE
April 2011
SOURCE
E-Journal of Chemistry;2011, Vol. 8 Issue 2, p594
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
New series of 5-(o-hydroxy phenyl)-2-[4″aryl-3″chloro-2″azetidinon-1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antifungal activity (MIC activity) was evaluated and compared with standard drugs of ketoconazole. Compounds 3c in the series has shown interesting antifungal activity against both C. albicans and A. niger fungus. In the gratifying result, most of the compounds were found to have moderate antifungal activity.
ACCESSION #
62086008

 

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