TITLE

Advances and Perspectives in Cell-Specific Aptamers

AUTHOR(S)
Wei Sun; Lupei Du; Minyong Li
PUB. DATE
January 2011
SOURCE
Current Pharmaceutical Design;1/1/2011, Vol. 17 Issue 1, p80
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
62004106

 

Related Articles

  • Bioinformatic Analysis of the Contribution of Primer Sequences to Aptamer Structures. Cowperthwaite, Matthew C.; Ellington, Andrew D. // Journal of Molecular Evolution;Jul2008, Vol. 67 Issue 1, p95 

    Aptamers are nucleic acid molecules selected in vitro to bind a particular ligand. While numerous experimental studies have examined the sequences, structures, and functions of individual aptamers, considerably fewer studies have applied bioinformatics approaches to try to infer more general...

  • Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation. Shigdar, Sarah; Macdonald, Joanna; O'Connor, Michael; Tao Wang; Dongxi Xiang; Al. Shamaileh, Hadi; Liang Qiao; Ming Wei; Shu-Feng Zhou; Yimin Zhu; Lingxue Kong; Bhattacharya, Santanu; ChunGuang Li; Wei Duan // Sensors (14248220);Oct2013, Vol. 13 Issue 10, p13624 

    Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of...

  • Peptide Nucleic Acids (PNAs) as Diagnostic Devices for Genetic and Cytogenetic Analysis. Pellestor, Franck; Paulasova, Petra; Hamamah, Samir // Current Pharmaceutical Design;Aug2008, Vol. 14 Issue 24, p2439 

    The peptide nucleic acids (PNAs) constitute a remarkable new class of synthetic nucleic acids analogs, based on peptide-like backbone. This structure gives to PNAs the capacity to hybridize with high affinity and specificity to complementary RNA and DNA sequences, and a great resistance to...

  • Biological Applications of the Receptor Mimetic Peptide Mastoparan. Jones, Sarah; Howl, John // Current Protein & Peptide Science;Dec2006, Vol. 7 Issue 6, p501 

    The receptor mimetic and mast cell degranulating peptide mastoparan (MP) translocates cell membranes as an amphipathic α-helix, a feature that is undoubtedly a major determinant of bioactivity through the activation of heterotrimeric G proteins. Chimeric combinations of MP with G...

  • KIR Polymorphisms Modulate Peptide-Dependent Binding to an MHC Class I Ligand with a Bw6 Motif. Colantonio, Arnaud D.; Bimber, Benjamin N.; Neidermyer Jr., William J.; Reeves, R. Keith; Alter, Galit; Altfeld, Marcus; Johnson, R. Paul; Carrington, Mary; O'Connor, David H.; Evans, David T. // PLoS Pathogens;Mar2011, Vol. 7 Issue 3, preceding p1 

    No abstract available.

  • A Mathematical Analysis of Multiple-Target Selex. Yeon-Jung Seo; Shiliang Chen; Nilsen-Hamilton, Marit; Levine, Howard // Bulletin of Mathematical Biology;Oct2010, Vol. 72 Issue 7, p1623 

    SELEX (Systematic Evolution of Ligands by Exponential Enrichment) is a procedure by which a mixture of nucleic acids can be fractionated with the goal of identifying those with specific biochemical activities. One combines the mixture with a specific target molecule and then separates the...

  • A microfluidic SELEX prototype. Hybarger, Glen; Bynum, Joseph; Williams, Robert F.; Valdes, James J.; Chambers, James P. // Analytical & Bioanalytical Chemistry;Dec2005, Vol. 384 Issue 1, p191 

    Aptamers are nucleic acid binding species capable of recognizing a wide variety of targets ranging from small organic molecules to supramolecular structures, including organisms. They are isolated from combinatorial libraries of synthetic nucleic acid by an iterative process referred to as SELEX...

  • Antiviral aptamers. Gopinath, S. C. B. // Archives of Virology;Dec2007, Vol. 152 Issue 12, p2137 

    Aptamers are rare nucleic acid ligands, which can be concocted in the laboratory from the randomized pool of molecules by affinity and amplification processes. Aptamers have several properties as they can be applied complementarily to antibodies and have several advantages over antibodies. In...

  • Residue propensities, discrimination and binding site prediction of adenine and guanine phosphates. Firoz, Ahmad; Malik, Adeel; Joplin, Karl H.; Ahmad, Zulfiqar; Jha, Vivekanand; Ahmad, Shandar // BMC Biochemistry;2011, Vol. 12 Issue 1, p20 

    Background: Adenine and guanine phosphates are involved in a number of biological processes such as cell signaling, metabolism and enzymatic cofactor functions. Binding sites in proteins for these ligands are often detected by looking for a previously known motif by alignment based search. This...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics