TITLE

Meal-Related Increases in Microvascular Vasomotion Are Impaired in Obese Individuals

AUTHOR(S)
JONK, AMY M.; HOUBEN, ALFONS J.; SCHAPER, NICOLAAS C.; DE LEEUW, PETER W.; SERNÉ, ERIK H.; SMULDERS, YVO M.; STEHOUWER, COEN D.
PUB. DATE
May 2011
SOURCE
Diabetes Care;May2011 Supplement 2, Vol. 34, pS342
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reviews data and evidence for microvascular dysfunction. These include impairment of insulin-stimulated microvascular perfusion and insulin resistance. Several conditions associated to obesity include insulin resistance, hypertension, cardiovascular disease and type 2 diabetes. Muscle capillary rarefaction and a disturbed balance of nitric oxide (NO) and electrophoretic type 1 (ET-1) are seen from obese individuals. The radioimmunoassay techniques used to measure plasma insulin concentrations are enumerated.
ACCESSION #
61968036

 

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