TITLE

Endothelial Dysfunction in Diabetes

AUTHOR(S)
AVOGARO, ANGELO; ALBIERO, MATTIA; MENEGAZZO, LISA; DE KREUTZENBERG, SAULA; FADINI, GIAN PAOLO
PUB. DATE
May 2011
SOURCE
Diabetes Care;May2011 Supplement 2, Vol. 34, pS285
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article outlines the mechanisms of endothelial dysfunction in diabetes, the role of endothelial progenitor cells (EPC) in cardiovascular homeostasis and the implications of EPC alterations in diabetes. Due to the adverse effects of hyperglycemia and oxidative stress on vascular biology, there is high risk of cardiovascular disease in type 2 diabetes. The strongest stimulus for EPC mobilization is tissue ischemia. Weak bone marrow mobilization, decreased proliferation and shortened survival are mechanisms underlying EPC reduction.
ACCESSION #
61968026

 

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