Glucokinase Activators for Diabetes Therapy

May 2011
Diabetes Care;May2011 Supplement 2, Vol. 34, pS236
Academic Journal
The article discusses the essential aspect of the role of glucokinase (GK) in glucose homeostasis, of the biochemical pharmacology of GK activators (GKA), and of the current status of GKA research and development and therapeutic application. The clinical characteristics of type 2 diabetes are described. Several diabetes complications include loss of vision, peripheral neuropathy, impaired kidney function, heart disease and stroke. Among hexokinase isoenzymes, GK is considered unique because it is a monomer with a molecular mass of 50 kilodaltons (kDa).


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