Insulin: Potential Negative Consequences of Early Routine Use in Patients With Type 2 Diabetes

May 2011
Diabetes Care;May2011 Supplement 2, Vol. 34, pS225
Academic Journal
The article focuses on the possible negative consequences of early routine use of insulin in patients with type 2 diabetes. A comparison of insulin secretion in type 1 and type 2 diabetes is described. The loss of the early phase of meal-stimulated insulin secretion is one of the initial abnormalities involving insulin secretion in type 2 diabetes. A diagram is presented illustrating the two intracellular pathways of insulin action. Some adverse effects of long-term intensive insulin treatment include hypoglycemia and increased mortality.


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