Pivotal Role of Timely Basal Insulin Replacement After Metformin Failure in Sustaining Long-Term Blood Glucose Control at a Target in Type 2 Diabetes

May 2011
Diabetes Care;May2011 Supplement 2, Vol. 34, pS220
Academic Journal
The article examines the role of timely basal insulin replacement after metformin failure to sustain long-term blood glucose control in type 2 diabetes. Early and aggressive blood glucose-lowering intervention are used in addressing macrovascular complications. A discussion on the outcomes of clinical studies which compared basal insulin and glucagon-like peptide (GLP)-1 agonists in type 2 diabetes is presented. Upon failure of metformin and lifestyle intervention, insulin will be initiated and the add-on treatment of sulfonylurea (SU) will be bypassed.


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