TITLE

Type 2 Diabetes Can Be Prevented With Early Pharmacological Intervention

AUTHOR(S)
DE FRONZO, RALPH A.; ABDUL-GHANI, MUHAMMAD
PUB. DATE
May 2011
SOURCE
Diabetes Care;May2011 Supplement 2, Vol. 34, pS202
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In the U.S., ~21 x 106 individuals have type 2 diabetes, and twice as many have impaired glucose tolerance (IGT). Approximately 40-50% of individuals with IGT will progress to type 2 diabetes over their lifetime. Therefore, treatment of high-risk individuals with IGT to prevent type 2 diabetes has important medical, economic, social, and human implications. Weight loss, although effective in reducing the conversion of IGT to type 2 diabetes, is difficult to achieve and maintain. Moreover, 40-50% of IGT subjects progress to type 2 diabetes despite successful weight reduction. In contrast, pharmacological treatment of IGT with oral antidiabetic agents that improve insulin sensitivity and preserve β-cell function--the characteristic pathophysiologncal abnormalities present in IGT and type 2 diabetes--uniformly have been shown to prevent progression of IGT to type 2 diabetes. The most consistent results have been observed with the thiazolidinediones (Troglitazone in the Prevention of Diabetes [TRIPOD], Pioglitazone in the Prevention of Diabetes [PIPOD], Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication [DREAM], and Actos Now for the Prevention of Diabetes [ACT NOW]), with a 50-70% reduction in IGT conversion to diabetes. Metformin in the U.S. Diabetes Prevention Program (DPP) reduced the development of type 2 diabetes by 31% and has been recommended by the American Diabetes Association (ADA) for treating high-risk individuals with IGT. The glucagon-like peptide-1 analogs, which augment insulin secretion, preserve β-cell function, and promote weight loss, also would be expected to be efficacious in preventing the progression of IGT to type 2 diabetes. Because individuals in the upper tertile of IGT are maximally/near-maximally insulin resistant, have lost 70-80% of their β-cell function, and have an ~10% incidence of diabetic retinopathy, pharmacological intervention, in combination with diet plus exercise, should be instituted.
ACCESSION #
61968012

 

Related Articles

  • Improvements in Cardiovascular Risk Factors Accompanied Improved Glycemic Control and Weight Reduction in Patients With Type 2 Diabetes Treated With Exenatide for 3.5y. Kendall, David; Blonde, Lawrence; Mac, Susanna; Xuesong Guan; Holcombe, John; Okerson, Ted; Kim, Dennis; Bhole, Deepak // Diabetes;Jun2007 Supplement 1, Vol. 56, pA149 

    The article focuses on a study on the improvements in cardiovascular risk factors, glycemic control and weight reduction in type 2 diabetes patients treated with exenatide in 3.5 years conducted in the U.S. It cites that treatment with exenatide in type 2 diabetics has been associated with...

  • The DIAMOND system in the treatment of type 2 diabetes mellitus in an obese patient. Kozakowski, Jarosław; Lebovitz, Harold E.; Kiciak, Adam; Zgliczyński, Wojciech; Tarnowski, Wiesław // Videosurgery & Other Miniinvasive Techniques / Wideochirurgia i;Dec2014, Vol. 9 Issue 4, p627 

    Obesity and type 2 diabetes mellitus have reached epidemic proportions worldwide. As the majority of antidiabetic medications are of limited efficacy and patient adherence to long-term therapy is one of the main limiting factors of effective blood glucose and body weight control, new therapies...

  • HbA1c targets. Mead, Mike // Update;4/15/2004, Vol. 68 Issue 7, p343 

    The article discusses how to make the best of the HbA 1c targets for diabetes. Here is summarised a strategy for achieving HbA 1c targets in patients with type 2 diabetes. While the modern management of type 2 diabetes can often focus on drug treatments, diet and exercise also play a crucial...

  • Hot Tub Therapy For People With Diabetes. Trecrod, Daniel // Diabetes Health;Aug/Sep2008, Vol. 17 Issue 4, p20 

    A reprint of the article "Hot Tub Therapy for People With Diabetes," by Daniel Trecroci, which appeared in the November 1999 issue of "Diabetes Health" is presented. It reports a study which found that hot tub therapy helped type 2 diabetics reduce their blood sugars, lose weight and improve...

  • Patient Handout: Diabetes Mellitus Type 2.  // Alternative Medicine Alert;Feb2008 Supplement, Vol. 11, pS1 

    The article offers information about diabetes mellitus type 2. The disease is a chronic condition wherein the body is experiencing problems transforming food into energy. Symptoms of diabetes include excessive thirst, weight loss and wounds that do not heal. The conventional way to treat the...

  • Stop Type 2 Diabetes Before You Get It. Voiland, Adam // U.S. News & World Report;12/25/2006, Vol. 141 Issue 24, p55 

    The article offers information on Type 2 diabetes in adults. Type 2 diabetes, or prediabetes, can be prevented with moderate exercise and weight loss. The condition occurs when blood sugar levels are higher than normal but not enough to be diagnosed as diabetes. The article recommends several...

  • Weight loss in type 2 diabetes.  // Practice Nurse;9/5/2008, Vol. 36 Issue 4, p6 

    The article discusses research being done on weight loss in patients diagnosed with type 2 diabetes. It references a study published in the August 12, 2008 online issue of "Diabetes Care." Study researchers followed 2,500 adults with type 2 diabetes for four years. They found that people who...

  • Diabetes cases rising and myths remain, report says.  // Medical Economics;4/10/2013, Vol. 90 Issue 7, p16 

    The article focuses on the findings of a national survey of primary care physicians (PCPs) which state that increasing number of type 2 diabetes cases and the need for patients to be better educated on the effects of the disease. According to chief medical officer David Horwitz, PCPs agree that...

  • Insulin Resistance: The Unintended Consequence of Fat Phobia and the Case for Ketosis. Wood, Sara // Townsend Letter;Jun2015, Issue 383, p86 

    The article presents insulin resistance (IR). Topics discussed include prediabetic elevation of blood glucose, type 2 diabetes and link between IR and obesity and heart disease. It argues that avoidance of fat as strategy for weight loss and reduction in serum lipids and replacement of dietary...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics