TITLE

Wilson's disease in Asia

AUTHOR(S)
Yue Zhang; Zi-Ying Wu
PUB. DATE
June 2011
SOURCE
Neurology Asia;Jun2011, Vol. 16 Issue 2, p103
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Wilson's disease is an autosomal recessive disorder of copper metabolism. The resultant accumulation of copper primarily damages the liver and brain, resulting in hepatic, neurological and psychiatric symptoms. There have been many recent studies advancing the understanding of Wilson's disease in Asia. There are indications that the incidence of Wilson's disease in parts of Asia may be relatively high. Many genetic studies have identified various hot spots in the ATP7B gene in a variety of the Asian populations. Screening of these hotspot mutations may thus be useful in confirming the diagnosis. Despite the advances in treatment, lack of familiarity by the health care profession resulting in late diagnosis, and poor access to treatment particularly among those from the developing economies remain areas of major concern.
ACCESSION #
61967560

 

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