TITLE

Cardiac resynchronisation therapy in patients with heart failure and a normal QRS duration: the RESPOND study

AUTHOR(S)
Foley, Paul W. X.; Patel, Kiran; Irwin, Nick; Sanderson, John E.; Frenneaux, Michael P.; Smith, Russell E. A.; Stegemann, Berthold; Leyva, Francisco
PUB. DATE
July 2011
SOURCE
Heart;Jul2011, Vol. 97 Issue 13, p1041
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives To evaluate the clinical response to cardiac resynchronisation therapy (CRT) in patients with heart failure and a normal QRS duration (<120 ms). Setting Single centre. Patients 60 patients with heart failure and a normal QRS duration receiving optimal pharmacological treatment (OPT). Interventions Patients were randomly assigned to CRT (n=29) or to a control group (OPT, n=31). Cardiovascular magnetic resonance was used in order to avoid scar at the site of left ventricular (LV) lead deployment. Main outcome measures The primary end point was a change in 6 min walking distance (6-MWD). Other measures included a change in quality of life scores (Minnesota Living with Heart Failure questionnaire) and New York Heart Association class. Results In 93% of implantations, the LV lead was deployed over non-scarred myocardium. At 6 months, the 6-MWD increased with CRT compared with OPT (p<0.0001), with more patients reaching a ≥25% increase (51.7% vs 12.9%, p=0.0019). Compared with OPT, CRT led to an improvement in quality-of-life scores (p=0.0265) and a reduction in NYHA class (p<0.0001). The composite clinical score (survival for 6 months free of heart failure hospitalisations plus improvement by one or more NYHA class or by ≥25% in 6-MWD) was better in CRT than in OPT (83% vs 23%, respectively; p
ACCESSION #
61892163

 

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