TITLE

Flow-Injection Chemiluminescence Analysis of Lomefloxacin in Drugs and Biological Fluids

AUTHOR(S)
Liqing Li; Hanwen Sun; Xueyan Chen
PUB. DATE
April 2008
SOURCE
Current Analytical Chemistry;Apr2008, Vol. 4 Issue 2, p152
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A new method was developed for the determination of lomefloxacin by using flow-injection chemiluminescence (CL) based on the reaction of Ce(IV)-sodium thiosulfate-lomefloxacin-sulfuric acid system. The CL conditions were investigated and optimized. The CL intensity was correlated linearly with concentration of lomefloxacin in the range of 1.0x10-5~6.0x10-2 g L-1. The determination limit (3s) is 3x10-6 g L-1. The relative standard deviation is 1.9% for 11 measurements of 2.0x10 L-4 g L-1 lomefloxacin. The method has been applied satisfactorily to determine lomefloxacin in drugs, serum and urine with the recovery of 97.0%~104.5%. The CL mechanism of the system was proposed.
ACCESSION #
61869044

 

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